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FLASH GENE
Symbol GRB14 contributors: mct - updated : 13-12-2016
HGNC name growth factor receptor-bound protein 14
HGNC id 4565
Location 2q24.3      Physical location : 165.349.332 - 165.478.360
Synonym symbol(s) GRBE
DNA
TYPE functioning gene
STRUCTURE 129.45 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5 GCA 2q24.3 grancalcin, EF-hand calcium binding protein KCNH7 2q24.3 potassium voltage-gated channel, subfamily H (eag-related), member 7 FIGN 2q24.2 fidgetin GRB14 2q22-q24 growth factor receptor-bound protein 14 KIAA0977 2q24.3 growth factor receptor-bound protein 14 FLJ39822 2q24.3 hypothetical protein FLJ39822 SCN3A 2q24.3 sodium channel, voltage-gated, type III, alpha SCN2A2 2q23-q24.3 sodium channel, voltage-gated, type II, alpha 2 TAIP-2 2q24.3 TGF-beta induced apotosis protein 2 GALNT3 2q24-q31 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) FLJ11457 2q31.1 hypothetical protein FLJ11457 SCN1A 2q24 sodium channel, voltage-gated, type I, alpha SCN9A 2q24 sodium channel, voltage-gated, type IX, alpha SCN7A 2q21-q23 sodium channel, voltage-gated, type VII, alpha CMYA3 2q31.1 cardiomyopathy associated 3 LOC90643 2q31.1 similar to Meningioma-expressed antigen 6/11 (MEA6) (MEA11) B3GALT1 2q24.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 STK39 2q24.3 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) LOC253782 2q31.1 hypothetical protein LOC253782 NOSTRIN 2q31.1 nitric oxide synthase trafficker AD024 IGRP 2q24-q31 nitric oxide synthase trafficker ABCB11 2q24.1 ATP-binding cassette, sub-family B (MDR/TAP), member 11
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2402 - 540 - 2009 19648926
13 - 2165 - 453 - 2009 19648926
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
 thyroid   highly
Hearing/Equilibriumear   highly
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidney   highly
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of Grb14 contains a polyproline-rich motif (PP)
  • a pleckstrin-homology (PH) domain
  • a family-specific BPS (between PH and SH2) region, binding as a pseudosubstrate inhibitor in the tyrosine kinase domain of the insulin receptor to suppress insulin signaling
  • a Ras-associating (RA) domain
  • a C-terminal Src-homology-2 domain (
  • HOMOLOGY
    interspecies homolog to C.elegans mig 10 gene
    Homologene
    FAMILY GRB7/10/14 family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • may play a role in signaling pathways that regulate growth and metabolism
  • inhibitor of insulin signaling, which binds to the activated insulin receptor tyrosine kinase domain and acts as a pseudosubstrate to inhibit its catalytic activity
  • could be a diverse regulator of insulin receptor mediated pathways in the retina (
  • may regulate signalling through the INSR by controlling its tyrosine dephosphorylation in a site-specific manner (
  • having an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling
  • GRB14, GPD1, and MSTN are potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
  • protects potentially light-dependent insulin receptor (INSR) activation in rod photoreceptors against dephosphorylation by protein tyrosine phosphatase 1B (
  • can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation (
  • adaptor protein that is involved in receptor tyrosine kinase signalling (
  • potential normal physiological modulator of cyclic-nucleotide-gated channel function (
  • adapter protein implicated in receptor tyrosine kinase signaling
  • phosphorylated GRB14 is an endogenous inhibitor of retinal protein tyrosine phosphatase PTPN1
  • inhibits insulin receptor (INSR) catalytic activity through interaction with the BPS domain and impedes peptide substrate binding
  • new role for GRB14 in finely tuning receptor signaling and modulating thyroid cancer progression
  • adapter protein implicated in receptor tyrosine kinase signaling
  • CHFR and GRB14 collaborate in a negative feedback loop controlling insulin-stimulated cell division
  • acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the SQSTM1-NFE2L2-NR1H3 signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • GRB14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma (PLCG1)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRB
  • interact with a number of receptor tyrosine kinases and signaling molecules
  • binding to the ankyrin repeat region of TNKS2 via its N- terminus
  • binding of the GRB14 SH2 domain to phosphorylated tyrosine residues in the C-tail of the activated FGFR1
  • binds to activated insulin receptors (INSR) and inhibits their catalytic activity (
  • interacts with the rod photoreceptor-specific cyclic-nucleotide-gated channel alpha subunit (CNGA1) and decreases its affinity for cyclic guanosine monophosphate (
  • GRB14 inhibits the activity of PTPN1, the major negative regulator of insulin receptor (INSR) signaling, in a phosphorylation-regulated manner
  • GRB14 is a novel binding partner of CEACAM3
  • phosphorylation status of the BPS region of GRB14 determines the positive or negative role it will play in INSR signaling
  • GRB14 interacts with insulin receptor (INSR) through the between PH and SH2 (BPS) domain
  • CHFR is a partner of the molecular adapter GRB14, an inhibitor of insulin signalling.
  • cell & other
    REGULATION
    Other phosphorylated on serine residues
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS