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Symbol GRB14 contributors: mct - updated : 13-12-2016
HGNC name growth factor receptor-bound protein 14
HGNC id 4565
Location 2q24.3      Physical location : 165.349.332 - 165.478.360
Synonym symbol(s) GRBE
TYPE functioning gene
STRUCTURE 129.45 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5 GCA 2q24.3 grancalcin, EF-hand calcium binding protein KCNH7 2q24.3 potassium voltage-gated channel, subfamily H (eag-related), member 7 FIGN 2q24.2 fidgetin GRB14 2q22-q24 growth factor receptor-bound protein 14 KIAA0977 2q24.3 growth factor receptor-bound protein 14 FLJ39822 2q24.3 hypothetical protein FLJ39822 SCN3A 2q24.3 sodium channel, voltage-gated, type III, alpha SCN2A2 2q23-q24.3 sodium channel, voltage-gated, type II, alpha 2 TAIP-2 2q24.3 TGF-beta induced apotosis protein 2 GALNT3 2q24-q31 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) FLJ11457 2q31.1 hypothetical protein FLJ11457 SCN1A 2q24 sodium channel, voltage-gated, type I, alpha SCN9A 2q24 sodium channel, voltage-gated, type IX, alpha SCN7A 2q21-q23 sodium channel, voltage-gated, type VII, alpha CMYA3 2q31.1 cardiomyopathy associated 3 LOC90643 2q31.1 similar to Meningioma-expressed antigen 6/11 (MEA6) (MEA11) B3GALT1 2q24.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 STK39 2q24.3 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) LOC253782 2q31.1 hypothetical protein LOC253782 NOSTRIN 2q31.1 nitric oxide synthase trafficker AD024 IGRP 2q24-q31 nitric oxide synthase trafficker ABCB11 2q24.1 ATP-binding cassette, sub-family B (MDR/TAP), member 11
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2402 - 540 - 2009 19648926
13 - 2165 - 453 - 2009 19648926
Type widely
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
 thyroid   highly
Hearing/Equilibriumear   highly
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidney   highly
Visualeyeretina    Homo sapiens
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
SystemCellPubmedSpeciesStageRna symbol
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
  • N-terminal domain of Grb14 contains a polyproline-rich motif (PP)
  • a pleckstrin-homology (PH) domain
  • a family-specific BPS (between PH and SH2) region, binding as a pseudosubstrate inhibitor in the tyrosine kinase domain of the insulin receptor to suppress insulin signaling
  • a Ras-associating (RA) domain
  • a C-terminal Src-homology-2 domain (
    interspecies homolog to C.elegans mig 10 gene
    FAMILY GRB7/10/14 family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play a role in signaling pathways that regulate growth and metabolism
  • inhibitor of insulin signaling, which binds to the activated insulin receptor tyrosine kinase domain and acts as a pseudosubstrate to inhibit its catalytic activity
  • could be a diverse regulator of insulin receptor mediated pathways in the retina (
  • may regulate signalling through the INSR by controlling its tyrosine dephosphorylation in a site-specific manner (
  • having an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling
  • GRB14, GPD1, and MSTN are potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
  • protects potentially light-dependent insulin receptor (INSR) activation in rod photoreceptors against dephosphorylation by protein tyrosine phosphatase 1B (
  • can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation (
  • adaptor protein that is involved in receptor tyrosine kinase signalling (
  • potential normal physiological modulator of cyclic-nucleotide-gated channel function (
  • adapter protein implicated in receptor tyrosine kinase signaling
  • phosphorylated GRB14 is an endogenous inhibitor of retinal protein tyrosine phosphatase PTPN1
  • inhibits insulin receptor (INSR) catalytic activity through interaction with the BPS domain and impedes peptide substrate binding
  • new role for GRB14 in finely tuning receptor signaling and modulating thyroid cancer progression
  • adapter protein implicated in receptor tyrosine kinase signaling
  • CHFR and GRB14 collaborate in a negative feedback loop controlling insulin-stimulated cell division
  • acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the SQSTM1-NFE2L2-NR1H3 signaling pathways
    signaling signal transduction
    a component
  • GRB14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma (PLCG1)
    small molecule
  • interact with a number of receptor tyrosine kinases and signaling molecules
  • binding to the ankyrin repeat region of TNKS2 via its N- terminus
  • binding of the GRB14 SH2 domain to phosphorylated tyrosine residues in the C-tail of the activated FGFR1
  • binds to activated insulin receptors (INSR) and inhibits their catalytic activity (
  • interacts with the rod photoreceptor-specific cyclic-nucleotide-gated channel alpha subunit (CNGA1) and decreases its affinity for cyclic guanosine monophosphate (
  • GRB14 inhibits the activity of PTPN1, the major negative regulator of insulin receptor (INSR) signaling, in a phosphorylation-regulated manner
  • GRB14 is a novel binding partner of CEACAM3
  • phosphorylation status of the BPS region of GRB14 determines the positive or negative role it will play in INSR signaling
  • GRB14 interacts with insulin receptor (INSR) through the between PH and SH2 (BPS) domain
  • CHFR is a partner of the molecular adapter GRB14, an inhibitor of insulin signalling.
  • cell & other
    Other phosphorylated on serine residues