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FLASH GENE
Symbol GRAP contributors: npt/ - updated : 10-01-2003
HGNC name GRB2-related adaptor protein
HGNC id 4562
Location 17p11.2      Physical location : 18.923.990 - 18.950.336
Synonym name growth factor receptor-bound protein 2-related adaptor protein
Synonym symbol(s) MGC64880
DNA
TYPE functioning gene
STRUCTURE 26.35 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located between SMS-REPM and SMS-REPP
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2089 25.2 217 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • arrangement of SH3-SH2 domain as in GRB2
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to C.elegans c14f5.5
    Homologene
    FAMILY
  • GRB2/sem-5/DRK family
  • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • Grb2-related adaptor protein 1
  • coupling tyrosine kinase to the RAS pathway
  • SH3/SH2 adaptor protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell to cell signaling
    a component
  • forming a stable complex with the BSR-ABL oncoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with cKIT
  • EPOR binding
  • ras guanine nucleotide exchange factor SOS1
  • BCR-ABL oncoprotein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS