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FLASH GENE
Symbol GPX5 contributors: mct - updated : 12-09-2012
HGNC name glutathione peroxidase 5 (epididymal androgen-related protein)
HGNC id 4557
Location 6p21.32      Physical location : 15.992 - 28.502.728
Synonym name epididymal androgen-related protein
Synonym symbol(s) EGLP, GPx-5, GSHPx-5
EC.number 1.1.1.19
DNA
TYPE functioning gene
STRUCTURE 8.94 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif Viral sequence   gene gag
MAPPING cloned Y linked N status provisional
Physical map
LOC391891 6 similar to olfactory receptor GA_x6K02T2QHY8-11688984-11689964 LOC391892 6 similar to Olfactory receptor 2B8 (Hs6M1-29P) LOC391893 6 similar to Olfactory receptor 1F12 (Hs6M1-35P) ZNF165 6p21.3 zinc finger protein 165 LOC391894 6 similar to Zinc finger protein 192 (LD5-1) ZNF435 6p21.33 zinc finger protein 435 ZNF192 6p21.3 zinc finger protein 192 LOC222701 6p21.33 similar to Zinc finger protein 192 (LD5-1) LOC391895 6 similar to hypothetical protein MGC42493 ZNF193 6p21..3 zinc finger protein 193 P1P373C6 C6orf194 6p21.33 chromosome 6 open reading frame 194 ZNF187 6p21.31 zinc finger protein 187 PGBD1 6p21.31 piggyBac transposable element derived 1 ZNF323 6p zinc finger protein 323 ZNF306 6p21.33 zinc finger protein 306 ZNF305 6p21.3 zinc finger protein 305 LOC391896 6 similar to Zinc finger protein 354A (Transcription factor 17) (Zinc finger protein eZNF) ZNF453 6p21.33 zinc finger protein 453 COX11P 6p23-p22 COX11 homolog, cytochrome c oxidase assembly protein (yeast) pseudogene TRLP1 6p25-q13 tRNA leucine (AAG) pseudogene 1 TRMEP1 6p25-q13 tRNA methionine elongator pseudogene 1 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) GPX5 6p21.32 glutathione peroxidase 5 (epididymal androgen-related protein) ZNF452 6p21.33 zinc finger protein 452 LOC282925 6p21.33 similar to 33 kDa protein LOC222693 6p21.33 similar to dJ207F6.1 (novel nucleolar protein NOP56 like protein) LOC391897 6 similar to ribosomal protein L13; 60S ribosomal protein L13; breast basic conserved protein 1 RFP 6p21.3 ret finger protein KRT18P1 6p21.3 keratin 18 pseudogene 1 ZNF311 6p21.33 zinc finger protein 311
RNA
TRANSCRIPTS type messenger
text multiple alternatively spliced variants but only one encoding an active glutathione peroxidase
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing 1452 25 221 epididymis-specific 1998 9639555
includes exons 1 to 5 and encodes the active form enzyme
4 splicing 1334 - 100 - 1998 9639555
lacking exon 3 and encoding an inactive enzyme
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemmale genital tractepididymis   Homo sapiens
 male systemmale genital tract    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gpx5
Homologene
FAMILY glutathione peroxidase family
CATEGORY chaperone/stress , enzyme
SUBCELLULAR LOCALIZATION extracellular
text secreted
basic FUNCTION
  • may protect cells and enzymes from oxidative dammage by catalyzing the reduction of hydrogen perodie, lipid peroxides and organic peroxides
  • may act to protect sperm form premature acrosome reaction in the epididymis
  • because of the very low level of expression of the active form, these functions remains to be demonstrated
  • key importance of GPX5 as an extracellular antioxidant designed to protect maturing mammalian spermatozoa from oxidative stress
  • GPX5 protein, and the epithelial proteins GPX1, GPX3, and cellular GPX4, all functioning in the mammalian epididymis at different stages of the sperm epididymal journey, and in different epididymis compartments
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with NME5 (NME5 expression plays a critical role in spermiogenesis by increasing the cellular levels of GPX5 to eliminate reactive oxygen species)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS