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FLASH GENE
Symbol GPX4 contributors: mct/npt/pgu - updated : 04-01-2010
HGNC name glutathione peroxidase 4 (phospholipid hydroperoxidase)
HGNC id 4556
Corresponding disease
HXALI hepoxilin A3 synthase-linked ichthyosis
Location 19p13.3      Physical location : 1.103.935 - 1.106.786
Synonym name
  • phospholipid hydroperoxidase
  • sperm nucleus glutathione peroxidase
  • hepoxilin A3 (HXA3) synthase
  • phospholipid hydroperoxide glutathione peroxidase,
  • mitochondrial
    Synonym symbol(s) PHGPx, snGPx, HXA3S, MCSP, GPX-4
    EC.number 1.11.1.12
    DNA
    TYPE functioning gene
    STRUCTURE 2.85 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC91978 19p13.3 hypothetical gene supported by BC009520 CDC34 19p13.3 cell division cycle 34 GZMM 19p13.3 granzyme M (lymphocyte met-ase 1) BSG 19p13.3 basigin (OK blood group) HCN2 19p13.3 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 POLRMT 19p13.3 polymerase (RNA) mitochondrial (DNA directed) FGF22 19p13.3 fibroblast growth factor 22 RNF126 19p13.3 ring finger protein 126 FSTL3 19p13 follistatin-like 3 (secreted glycoprotein) PALM 19p13.3 paralemmin LOC126353 19p13.3 hypothetical protein LOC126353 PTBP1 19p13.3 polypyrimidine tract binding protein 1 FLJ11535 19p13.3 hypothetical protein FLJ11535 AZU1 19p13.3 azurocidin 1 (cationic antimicrobial protein 37) PRTN3 19p13.3 proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) ELA2 19p13.3 elastase 2, neutrophil DF 19p13.3 D component of complement (adipsin) TRAP95 MGC16353 19p13.3 hypothetical protein MGC16353 GPR54 19p13.3 G protein-coupled receptor 54 DRIL1 19p13.3 dead ringer-like 1 (Drosophila) WDR18 19p13.3 WD repeat domain 18 GRIN3B 19p13.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B C19orf6 19p13.3 chromosome 19 open reading frame 6 CNN2 21q11 calponin 2 ABCA7 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 HA-1 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 POLR2E 19p13.3 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa GPX4 19p13.3 glutathione peroxidase 4 (phospholipid hydroperoxidase) KIAA0963 19p13.3 Homo sapiens KIAA0963 protein (KIAA0963), mRNA. STK11 19p13.3 serine/threonine kinase 11 (Peutz-Jeghers syndrome) MGC40084 19p13.3 hypothetical protein MGC40084 ATP5D 19p13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit MIDN 19pter-p13.3 midnolin MGC39338 19p13.3 hypothetical protein MGC39338 CIRBP 19p13.3-p13.2 cold inducible RNA binding protein FLJ20640 19p13.3 hypothetical protein FLJ20640 EFNA2 19p13.3 ephrin-A2 LOC388488 19 similar to Dip1-associated protein C MUM-1 NDUFS7 19p13 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) GAMT 19p13.3 guanidinoacetate N-methyltransferase DAZAP1 19p13.3 DAZ associated protein 1 RPS15 19p13.3 ribosomal protein S15 APCL 19p13.3 ribosomal protein S15 FLJ36666 19p13.3 hypothetical protein FLJ36666 PCSK4 19p proprotein convertase subtilisin/kexin type 4 DP1L1 19p13.3 polyposis locus protein 1-like 1 LOC339366 19p13.3 hypothetical protein LOC339366 LOC126520 19p13.3 hypothetical protein LOC126520 MBD3 19p13.3 methyl-CpG binding domain protein 3 UQCR 19p13.3 ubiquinol-cytochrome c reductase (6.4kD) subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 942 - 197 - 2009 19744930
    short form Gpx4 protein is present in somatic tissue mitochondria and is essential for survival and protection against apoptosis in mice
    7 - 964 - 227 - 2009 19744930
    - - 1031 - 234 - 2009 19744930
    long form Gpx4 protein is important for male fertility in mice
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivesalivary gland   highly
     stomach   highly
    Endocrineparathyroid   highly
    Reproductivemale systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Gpx4
    Homologene
    FAMILY
  • glutathione peroxidase family
  • selenium-dependent glutathione peroxidases family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,nucleus,nucleolus
    text at least three isoforms in testis: cytosolic, mitochondrial and nuclear
    basic FUNCTION
  • glutathione peroxidase, free radical detoxification, catabolic pathway of activated oxygen species, oxydoreductase
  • catalyzing the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage
  • playing an indispensable role for structural integrity of spermatozoa and to codetermine sperm motility and viability
  • essential antioxidant enzyme having multiple functions
  • playing a pivotal role in brain development and function
  • multifunctional and it acts as a reducing enzyme of peroxidized phospholipids and thiols and as a structural protein
  • GPX5 protein, and the epithelial proteins GPX1, GPX3, and cellular GPX4, all functioning in the mammalian epididymis at different stages of the sperm epididymal journey, and in different epididymis compartments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GRSF1 up-regulates translation of GPX4 mRNA and implicate the two proteins in embryonic brain development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HXALI
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in blood of women with preeclampsia
    Susceptibility to sterility and infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS