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FLASH GENE
Symbol GPX3 contributors: mct - updated : 10-10-2012
HGNC name glutathione peroxidase 3 (plasma)
HGNC id 4555
Location 5q33.1      Physical location : 150.399.998 - 150.408.553
Synonym symbol(s) GSHP, GPx-P, GSHPx-3, GSHPx-P
EC.number 1.11.1.9
DNA
TYPE functioning gene
STRUCTURE 8.55 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure Sp-1- and hypoxia-inducible factor-1-binding sites
MAPPING cloned Y linked   status confirmed
Physical map
PERC 5q33.1 glutamate-ammonia ligase (glutamine synthase)-like 1 PDE6A 5q31.3 phosphodiesterase 6A, cGMP-specific, rod, alpha SLC26A2 5q31.3 solute carrier family 26 (sulfate transporter), member 2 TIGD6 5q32 tigger transposable element derived 6 RPS20P4 5q33-qter ribosomal protein S20 pseudogene 4 CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog RPL7P 5q33.3 ribosomal protein L7 pseudogene PDGFRB 5q31.3 platelet-derived growth factor receptor, beta polypeptide CDX1 5q31.3 caudal type homeo box transcription factor 1 SLC6A7 5q31-q32 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha LOC340075 5q33.1 similar to RIKEN cDNA 9330196J05 TCOF1 5q32-q33.1 Treacher Collins-Franceschetti syndrome 1 CD74 5q31.3 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) RPS14 5q32 ribosomal protein S14 NDST1 5q31.3-q32 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 SYNPO 5q33.1 synaptopodin MYOZ3 5q33.1 myozenin 3 FLJ10290 5q33.1 hypothetical protein FLJ10290 DCTN4 5q31-q32 dynactin 4 (p62) NID67 5q33.1 putative small membrane protein NID67 LRG47 5q33.1 LRG-47-like protein ZNF300 21 zinc finger protein 300 GPX3 5q23 glutathione peroxidase 3 (plasma) TNIP1 5q32-q33.1 TNFAIP3 interacting protein 1 ANXA6 5q32 annexin A6 DKFZP434C171 5q33.1 DKFZP434C171 protein GM2A 5q32 GM2 ganglioside activator protein SLC36A3 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 3 SLC36A2 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 2 LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421 SLC36A1 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1 FAT2 5q31-q32 FAT tumor suppressor homolog 2 (Drosophila) SPARC 5q32 secreted protein, acidic, cysteine-rich (osteonectin) ATOX1 5q32-q33 ATX1 antioxidant protein 1 homolog (yeast) LOC389338 5 LOC389338 G3BP 5q33.3 LOC389338 GLRA1 5q32 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1779 - 226 - 2012 22461624
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreast  lowly
 male systemmale genital tractepididymis highly Homo sapiens
Respiratoryrespiratory tractlarynx  lowly
Urinarykidney   highly Homo sapiens
Visualeye   lowly
cell lineage
cell lines
fluid/secretion plasma
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Gpx3
Homologene
FAMILY glutathione peroxidase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
text plasma
basic FUNCTION
  • involved in free radical detoxification and reduction of hydrogen peroxide
  • catalyzing the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione
  • functioning in the protection of cells against oxidative damage
  • having potent extracellular antioxidant activity
  • major antioxidative enzyme that was induced upon nontoxic proteasome inhibition in endothelial cells
  • borderline defense mechanism of endothelial cell-derived GPx-3 to protect the vasculature from oxidative stress
  • GPX5 protein, and the epithelial proteins GPX1, GPX3, and cellular GPX4, all functioning in the mammalian epididymis at different stages of the sperm epididymal journey, and in different epididymis compartments
  • from the blood binds to basement membranes of specific epithelial cells and the cells modify their basement membranes to cause the binding
  • importance of this plasma antioxidant enzyme in regulating platelet activity, endothelial function, platelet-dependent thrombosis, and vascular thrombotic propensity
  • plasma antioxidant enzyme, maintaining genomic integrity by inactivating reactive oxygen species (ROS), known DNA-damaging agents and mediators of cancer chemotherapy response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism
    signaling
  • catabolic pathway of activated oxygen species
  • a novel signaling pathway of GPX3-TP53I3 in the regulation of cell death in prostate cancer
  • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    selenocysteine
    protein
  • MAF may be transcriptional regulator of GPX3 expression and modulate the antioxidative pathway in the kidney
  • cell & other
    REGULATION
    Other regulated by regulated by hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by hypermethylation in Barrett's tumorigenesis
    tumoral     --over  
    by hypomethylation in leukemia stem cells
    tumoral     --low  
    by promoter hypermethylation is frequently observed in a wide spectrum of malignancies
    constitutional       loss of function
    results in a prothrombotic state and vascular dysfunction that promotes platelet-dependent arterial thrombosis
    tumoral     --low  
    through promoter hypermethylation in esophageal squamous cell carcinoma
    Susceptibility to cerebral venous thrombosis (CVT)
    Variant & Polymorphism other
  • a novel GPX3 promoter haplotype is a strong, independent risk factor for CVT
  • Candidate gene
    Marker potential biomarker of esophageal squamous cell carcinoma
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may be a therapeutic target for insulin resistance and diabetes mellitus
    ANIMAL & CELL MODELS
  • GPx-3(-/-) mice displayed increased plasma levels of soluble P-selectin and decreased plasma cyclic cGMP compared with wild-type mice