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FLASH GENE
Symbol GPX2 contributors: mct - updated : 30-01-2008
HGNC name glutathione peroxidase 2 (gastrointestinal)
HGNC id 4554
Location 14q24.1      Physical location : 65.405.871 - 65.409.531
Synonym name gastrointestinal glutathione peroxidase 2
Synonym symbol(s) GSHPX-GI, GI-GPx, GPRP
EC.number 1.11.1.9
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure a unique responsive element was found in the promoter of the GPX2 gene that can be activated and bound by TP63 but not TP53
MAPPING cloned Y linked N status confirmed
Physical map
LOC390485 14 similar to ribosomal protein L31 GCATP 14q23.2 glycine C-acetyltransferase pseudogene LOC112840 14q23.2 similar to RIKEN cDNA 2600001A11 gene HSPEP2 14 heat shock 10kDa protein 1 (chaperonin 10) pseudogene 2 SGPP1 14q23.1 sphingosine-1-phosphate phosphatase 1 EIF2S2P 14q23.2 eukaryotic translation initiation factor 2, subunit 2 beta, pseudogene SYNE2 14q23.1-q23.2 spectrin repeat containing, nuclear envelope 2 ESR2 14q24.1 estrogen receptor 2 (ER beta) MTHFD1 14q24 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase AKAP5 14q21-q24 a kinase (PRKA) anchor protein 5 ZNF46 14q22-q24 zinc finger protein 46 (KUP) ZBTB1 14q22.1-q22.3 zinc finger and BTB domain containing 1 HSPA2 14q22 heat shock 70kDa protein 2 C14orf50 14q23.2 chromosome 14 open reading frame 50 NUP50P 14 nucleoporin 50 pseudogene KIAA0599 14q23.3 KIAA0599 SPTB 14q22-q23.2 spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) C14orf52 14q23.2 chromosome 14 open reading frame 52 GPX2 14q24.1 glutathione peroxidase 2 (gastrointestinal) LOC390487 14 similar to Ras-related protein Rab-15 FNTB 14q23.1 farnesyltransferase, CAAX box, beta MAX 14q23.1 MAX protein LOC390488 14 similar to 60S ribosomal protein L21 RPL36AP2 14 ribosomal protein L36a pseudogene 2 PTBP1P 14 polypyrimidine tract binding protein 1 pseudogene FUT8 14q24.3 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) RPL21P8 14 ribosomal protein L21 pseudogene 8 NCOA4P 14 nuclear receptor coactivator 4 pseudogene LOC390489 14 similar to Ferritin heavy chain (Ferritin H subunit) NSEP1P 14q23.2 nuclease sensitive element binding protein 1 pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1024 - 190 - Naiki-Ito (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
 liver    
 stomach   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • glutathione peroxidase involved in free radical detoxification
  • involved in transcriptional response to exogenous redox agents and catabolic pathway of activated oxygen species
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein direct target of TP63, inhibiting oxidative stress-induced apoptosis in a TP53-dependent manner
    cell & other
    REGULATION
    activated by TP63
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS