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FLASH GENE
Symbol GPT2 contributors: mct/npt - updated : 22-12-2009
HGNC name glutamic pyruvate transaminase (alanine aminotransferase) 2
HGNC id 18062
Location 16q12.1      Physical location : 46.918.307 - 46.965.200
Synonym name
  • alanine aminotransferase 2
  • glutamate pyruvate transaminase 2
    • Synonym symbol(s) ALT2, AAT2
    EC.number 2.6.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 46.09 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3963 - 523 - Yang, Glinghammar (2009)
    12 - 3879 - 423 moderatly kidney, liver, heart, fat Yang, Glinghammar (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal glandcortex  highly
     pancreasislet of Langerhans  highly
    Nervousnerve    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal targeting signal
  • complete domain amminotran 1 and aminotran 2
    • HOMOLOGY
    interspecies homolog to rattus Gpt2
    homolog to murine Gpt2
    intraspecies homolog to ALT1
    Homologene
    FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
  • alanine aminotransferase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text in skeletal muscle cells, localisation to the mitochondrial fraction and endoplasmatic reticulum (ER), but not to the cytosol (Glinghammar 2009)
    basic FUNCTION
  • contributing to the homeostasis of fatty acid metabolism and storage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid , carbohydrate , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS