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FLASH GENE
Symbol GPT contributors: mct - updated : 22-12-2009
HGNC name glutamic-pyruvate transaminase (alanine aminotransferase)
HGNC id 4552
Location 8q24.3      Physical location : 145.729.464 - 145.732.554
Synonym name
  • alanine aminotransferase 1
  • glutamate pyruvate transaminase 1
    • Synonym symbol(s) ALT1, GPT1, ALT, AAT1
    EC.number 2.6.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 3.09 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1896 - 496 - 2009 19360321
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestiveliver   highly Homo sapiens
    Nervousbrain     Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac moderately Homo sapiens
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
  • alanine aminotransferase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text in hepatocytes, only localised to the cytosol and ER, with no detection in mitochondria
    basic FUNCTION
  • glutamic-pyruvate transaminase (alanine aminotransferase)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes mellitus and cardiovascular disease
    Variant & Polymorphism other significantly associated with an adverse metabolic and atherothrombotic risk profile
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS