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FLASH GENE
Symbol GPSM1 contributors: mlc/npt - updated : 04-01-2008
HGNC name G-protein signalling modulator 1 (AGS3-like, C. elegans)
HGNC id 17858
Location 9q34.3      Physical location : 139.221.931 - 139.254.057
Synonym name
  • activator of G-protein signaling 3
  • Synonym symbol(s) AGS3, DKFZP727I051
    DNA
    TYPE functioning gene
    STRUCTURE 23.00 kb     13 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1959 72.1 652 - Izaki (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   moderately
    Nervousbrain   highly
    Reproductivefemale systemplacenta  moderately
     male systemtestis  moderately
    Respiratorylung   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscular    
    Nervouscentralwhite matter  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen, pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal seven tetratricopeptide repeats (the TPR domain), a mediator of protein-protein interaction
  • one WH1 domain
  • WH2 domain
  • C-terminal four G protein regulatory motifs [the GPR or GoLoco domain, a modulator of G protein signaling
  • HOMOLOGY
    interspecies ortholog to murine Gpsm1
    ortholog to rattus Ags3
    Homologene
    FAMILY
  • GPSM family
  • CATEGORY regulatory , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • having GTPase activator activity, and involved in signal transduction
  • playing a critical role in drug addiction
  • involved in an early event during the autophagic pathway probably prior to the formation of the autophagosome
  • playing a potential role in the formation or maintenance of neural plasticity
  • modulating the protein trafficking along the transgolgi/network/plasma membrane/endosome loop
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS