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FLASH GENE
Symbol GPS1 contributors: mct/npt - updated : 05-05-2009
HGNC name G protein pathway suppressor 1
HGNC id 4549
Location 17q25.3      Physical location : 80.009.762 - 80.015.346
Synonym name
  • photomorphogenetic, Arabidopsis,homolog) subunit I
  • COP9 signalosome complex subunit 1
  • JAB1-containing signalosome subunit 1
  • arabidopsis FUS6/COP11 homolog
  • signalosome subunit 1
  • Synonym symbol(s) COPS1, CSN1, MGC71287, SGN1
    DNA
    TYPE functioning gene
    STRUCTURE 5.58 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388432 17 similar to dysferlin-interacting protein 1 P4HB 17q25.2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) ARHGDIA 17q25.3 Rho GDP dissociation inhibitor (GDI) alpha THOC4 17q25.3 THO complex 4 ANAPC11 17q25.3 APC11 anaphase promoting complex subunit 11 homolog (yeast) NPB 17q25.3 preproneuropeptide B LOC388433 17 LOC388433 PCYT2 17q25.3 phosphate cytidylyltransferase 2, ethanolamine SIRT7 17q25 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) MGC13090 17q25.3 hypothetical protein MGC13090 MAFG 17q25 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) LOC92659 17q25.3 hypothetical protein BC009233 PYCR1 17q25.3 pyrroline-5-carboxylate reductase 1 LOC255275 17q25.3 similar to myeloid-associated differentiation marker LOC147111 17q25.3 hypothetical protein LOC147111 ASPSCR1 17q25 alveolar soft part sarcoma chromosome region, candidate 1 STRA13 17q25.3 stimulated by retinoic acid 13 MGC20806 17q25.3 hypothetical protein MGC20806 RAC3 10q25.3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) DCXR 17q25.3 dicarbonyl/L-xylulose reductase GPS1 17q25.3 G protein pathway suppressor 1 PP3111 17q25.3 PP3111 protein FASN 17q25 fatty acid synthase FLJ23754 17q25.3 hypothetical protein FLJ23754 LOC284001 17q25.3 hypothetical protein LOC284001
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1870 56.7 491 - Spain, Ewing (2007)
    13 - 2364 - 527 - Spain, Ewing (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PCI (Proteasome,COP9,initiation factor 3) domain
  • INT6 domain
  • NIP1 and TRIP15 domain
  • HOMOLOGY
    interspecies homolog to murine Gps1
    Homologene
    FAMILY
  • CSN1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • potential cellular regulator modulating multiple signaling pathways
  • phosphorylating IKBA, JUN, NFKB1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    suppressor of G-protein and mitogen activated protein-kinase mediated pathways
    a component
  • component of a signalosome complex GPS1 450kDa including COPS3, COPS4, COPS5/JAB1, COPS6, COPS7A, COPS7B, GPS1, TRIP15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ASB4 to inhibits JNK activity (Li 2007)
  • GPS1 targets SENP8 for protein degradation, and GPS1-SENP8 interaction that affects SENP8 protein levels presumably balances cellular deneddylase activity
  • cell & other
    REGULATION
    activated by protein-kinase mediated pathways
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS