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FLASH GENE

Symbol

GPRIN1

contributors: mct - updated : 15-10-2013

HGNC name	G protein-regulated inducer of neurite outgrowth 1
HGNC id	24835

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q35.2      Physical location : 176.022.802 - 176.037.131
Synonym symbol(s)	KIAA1893, GRIN1, GRIN

DNA

TYPE	functioning gene
STRUCTURE	21.54 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052899 2 - 4208 NP_443131 102 1008 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific SELECTED Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Gprin1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	with GPRIN1 and GPRIN3, may function as a downstream effector for GNAO1 to regulate neurite growth
	signaling molecule coexpression of which with constitutively active form of GNAO1 can stimulate neurite extensions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

	GNAO1-GPRIN1 pathway could mediate significant roles in neuronal migration and differentiation at embryonic stages and exert functions in wiring and/or maintenance of specific neural circuitries at postnatal to adult stages
	modulates SPRY2 repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation

a component

INTERACTION

DNA

RNA

small molecule

protein	functions as a downstream target for GNAO1 (binding of activated GNAO1 to GPRIN1 induces activation of CDC42, which leads to morphological changes in neuronal cells)
	SPRY2 is an interacting partner of GPRIN1
	GNAO1 interacts with GPRIN1 and outcompetes GPRIN1 from bound SPRY2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS