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FLASH GENE
Symbol GPRC6A contributors: mct - updated : 08-04-2015
HGNC name G protein-coupled receptor, family C, group 6, member A
HGNC id 18510
Location 6q22.1      Physical location : 117.113.247 - 117.150.198
Synonym name
  • G-protein coupled receptor GPCR33
  • predicted with SOSUI analysis
  • seven transmembrane helix receptor
  • Synonym symbol(s) GPCR, bA86F4.3, hGPCR33
    DNA
    TYPE functioning gene
    STRUCTURE 36.97 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2860 104 926 - 2007 17478059
    variant 1
    6 splicing 2357 84 751 - 2007 17478059
    less abundant as isoform 1
    5 splicing 2669 96 855 - 2007 17478059
    less abundant than isoform 1
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine     Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage   
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte Homo sapiens
    Digestivegoblet Homo sapiens
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a seven-transmembrane (7TM) domain
  • an unusually long amino-terminal domain (ATD) of 590 amino acids
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cation-, calcimimetic-, and osteocalcin-sensing receptor
  • may mediate extracellular calcium-sensing responses in osteoblasts
  • may act as a regulatory component of the urea cycle
  • may function as the receptor component of a novel cellular transmitter system in mammals
  • cation-, calcimimetic-, and osteocalcin-sensing receptor and a candidate for mediating extracellular calcium-sensing responses in osteoblasts and possibly other tissues
  • directly participates in the regulation of osteoblast-mediated bone mineralization and may mediate the anabolic effects of extracellular amino acids, osteocalcin, and divalent cations in bone
  • calcium and amino acid sensing GPCR, transducing the non-genomic effects of testosterone and other steroid
  • is functionally important in regulating non-genomic effects of androgens in multiple tissues
  • may function as an anabolic receptor coordinating the responses of multiple tissues to changes in nutrients and other factors
  • sensing properties of GPRC6A, along with its responsiveness to anabolic steroids, may provide a means to coordinate nutritional and hormonal anabolic signals in multiple organs
  • role for GPRC6A in L-arginine-induced insulin release and glucose metabolism under normal physiological conditions
  • serves as a sensor and mediator of the rapid action of testosterone in epidermal keratinocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • speculated to form covalently linked dimers through cysteine disulfide linkage in the extracellular amino-terminal domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling
  • BGLAP regulates beta-cell replication in a cyclin D1-dependent manner by signaling through the GPRC6A receptor expressed in these cells
  • testosterone stimulates DUOX1 activity through GPRC6A in skin keratinocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for mediating extracellular calcium-sensing responses in osteoblasts and possibly other tissues
  • GPRC6A is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    molecular target for regulating prostate growth and cancer progression
    ANIMAL & CELL MODELS
  • GPRC6A null (GPRC6A(-/-) mice exhibit multiple metabolic abnormalities including osteopenia
  • loss of GPRC6A retarded the progress and improved survival of a mouse model of prostate cancer
  • Gprc6A-null mice exhibit a mild metabolic syndrome phenotype characterized by hyperglycemia, decreased serum insulin levels, glucose intolerance, and insulin resistance