Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPRC5C contributors: - updated : 25-07-2006
HGNC name G protein-coupled receptor, family C, group 5, member C
HGNC id 13309
Location 17q25      Physical location : 72.427.666 - 72.443.566
Synonym name
  • retinoic acid gene 3 metabotropic glutamate receptor-like
  • retinoic acid-induced gene 3 protein
  • Synonym symbol(s) RAIG3, RAIG-3
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ40319 17q25.2 hypothetical protein FLJ40319 RPL38 17q22 ribosomal protein L38 TTYH2 17q24 Tweety homolog 2 (Drosophila) DNAI2 17q25 dynein, axonemal, intermediate polypeptide 2 FLJ37300 17q25.2 hypothetical protein FLJ37300 LOC388419 17 similar to galectin 3 binding protein; L3 antigen; Mac-2-binding protein; serum protein 90K GPR142 17q25.2 G protein-coupled receptor 142 GPRC5C 17q25 G protein-coupled receptor, family C, group 5, member C CMRF-35H 17q25.2 leukocyte membrane antigen TREM5 17q25 leukocyte membrane antigen CMRF35 17q25.2 leukocyte membrane antigen LOC342509 17q25.2 similar to CMRF35 antigen precursor (CMRF-35) FLJ31882 17q25.2 hypothetical protein FLJ31882 LOC390813 17 similar to NKIR protein IREM2 17q25.2 immune receptor expressed on myeloid cells 2 RAB37 17q25.2 RAB37, member of RAS oncogene family NKIR 17q25.2 NK inhibitory receptor precursor SLC9A3R1 17q24.2-q24.3 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1 DKFZP564C103 17q25.2 DKFZP564C103 protein FLJ20255 17q25.2 hypothetical protein FLJ20255 GRIN2C 17q25 glutamate receptor, ionotropic, N-methyl D-aspartate 2C FDXR 17q24-q25 ferredoxin reductase LOC283985 17q25.2 similar to delta 5 fatty acid desaturase USH1G 17q25.2 Usher syndrome 1G (autosomal recessive) OTOP2 17q25.2 otopetrin 2 OTOP3 17q25.2 otopetrin 3 C17orf28 17q25.1 chromosome 17 open reading frame 28 HUMPPA 17q25.2 paraneoplastic antigen ICT1 17q25.2 immature colon carcinoma transcript 1 ATP5H 12q13 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d LOC390814 17 similar to Hypothetical protein KIAA0176 SLC16A5 17q25.3 solute carrier family 16 (monocarboxylic acid transporters), member 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2389 52.8 486 - Robbins
  • 4 exons
  • - splicing 1836 49.3 453 - Robbins
  • 4 exons
  • differing in the 5' UTR and coding region compared to variant 1
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   predominantly
    Endocrinepancreas   moderately
    Nervousbrain   moderately
     brainhindbraincerebellum  
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a signal peptide
  • seven transmembrane alpha helices
  • eight hydrophobic segments
  • a short aminoterminal domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gprc5c (88.2pc)
    ortholog to murine Gprc5c (89.6pc)
    Homologene
    FAMILY
  • orphan G protein-coupled receptor, family C, group 1, member 5C
  • G-protein coupled receptor 3 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localized in the plasma membrane and perinuclear vesicles
  • cell membrane (multi-pass membrane protein)
  • cytoplasmic vesicle membrane (multi-pass membrane protein)
  • basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by all-trans retinoic acid (ATRA)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS