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FLASH GENE
Symbol GPRC5B contributors: mct - updated : 12-07-2016
HGNC name G protein-coupled receptor, family C, group 5, member B
HGNC id 13308
Location 16p12.3      Physical location : 19.870.294 - 19.896.151
Synonym name
  • retinoic acid gene 2 metabotropic glutamate receptor-like
  • Synonym symbol(s) RAIG2, RAIG-2
    DNA
    TYPE functioning gene
    STRUCTURE 27.08 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2870 - 403 - 2000 10783259
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly Homo sapiens
    Hearing/Equilibriumearinnercochlea moderately
    Nervousbrainforebraincerebral cortex predominantly Mus musculus
     nervecranial nerve  moderately
    Reproductivefemale systemovary  moderately
     male systemtestis  moderately
    Urinarybladder   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) with a short extracellular N terminal domain
  • conjugated GlycoP
    isoforms Precursor a 27 aa signal peptide of 3.1 kda, a 376 mature peptide of 41.7 kda
    HOMOLOGY
    interspecies homolog to rattus Gprc5b (87.1 pc)
    homolog to murine Gprc5b (87.6 pc)
    intraspecies paralog to RAIG1,RAIG3
    Homologene
    FAMILY
  • type 3 G protein-coupled receptor family
  • group C family of G protein-coupled receptors (GPCRs)
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleolus
    text
  • cytoplasmic vesicle membrane
  • basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
  • may be a major node in adipose signaling systems linking diet-induced obesity to type 2 diabetes
  • GPRC5B-mediated signalling is associated with the proper regulation of CTNNB1 signalling, a pathway crucial for progenitor fate decision
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
  • visual perception
  • Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway
  • adaptor protein CD2AP-mediated internalization following cell surface delivery appears to contribute to the Golgi accumulation of GPRC5B, possibly in parallel with biosynthetic/secretory trafficking from the endoplasmic reticulum
  • cell & other
    REGULATION
    induced by all-trans retinoic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    pharmacological targeting of GPRC5B might provide a novel means therapy for the treatment and prevention of type 2 diabetes
    ANIMAL & CELL MODELS
    Gprc5b-deficient mice were protected from diet-induced obesity and insulin resistance because of reduced inflammation in their white adipose tissue