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FLASH GENE
Symbol GPRC5A contributors: mct/npt - updated : 03-02-2010
HGNC name G protein-coupled receptor, family C, group 5, member A
HGNC id 9836
Location 12p13.1      Physical location : 13.043.955 - 13.066.598
Synonym name
  • retinoic acid gene 1 metrabotropic glutamate receptor-like
  • retinoic acid induced 3
  • Synonym symbol(s) RAIG1, RAI3, GPCR5A
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text in opposite orientation with GPRC5D
    STRUCTURE 22.64 kb     4 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • 5prime upstream region of the GPRC5A gene was found to contain two potential RAR/RXR binding sites (RAREs) and one VDR/RXR binding site with direct repeat 5 (DR5) motifs designated DR5I (-489 to -473), DR5II (-136 to -120) and DR5III (-81 to -65) (DR5II and DR5III but not DR5I were conserved among vertebrates) (Ye 2009)
  • only DR5III is the functional RARE binding site for mediating induction of GPRC5A (Ye 2009)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2856 40.1 357 - Cheng, Hirano (2006)
    - - - 6800 - - - Cheng
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestine   highly
     stomach   highly
    Endocrinepancreas    
    Reproductivemale systemprostate   
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a short N terminal domain
  • a potential N-linked glycosylation site
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • functions as a tumor suppressor in lung cancer
  • may play a role in embryonic development and epithelial cell differentiation
  • may play a role in the proliferation of breast cancer cells (Jorissen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by all-trans-retinoic acid in squamous carcinoma cell lines (ATRA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    both mRNA and protein were abundantly expressed in breast carcinoma (Jorissen 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS