basic FUNCTION
| proton-sensing G-protein coupled receptor involved in bone metabolism, in the regulation of respiration, and cardiovascular function |
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proton-sensing G-protein-coupled receptor (GPCR) implicated in osteoblast and osteoclast function |
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acting as a proton-sensing receptor stimulating inositol phosphate formation |
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is involved in osteoclastogenesis |
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may be involved in the regulation of plasma membrane transport proteins and intra- and/or extracellular pH |
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involvement of GPR68 in acidic extracellular environment may be an underlying mechanism responsible for bone pain in osteoporosis or bone metastasis without clinically proved fractures |
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pathophysiological role for pH-sensing receptor GPR68 during the pathogenesis of mucosal inflammation |
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GPR4, GPR65 and GPR68 are G protein-coupled receptors that aid cells to sense and survive conditions of acidic pH |
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pH-sensing receptor GPR68 that improves barrier function of epithelial cells and inhibits migration in an acidic environment |
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CASR and GPR68 reciprocally inhibit signaling through each other in central neurons, but strong intracellular acidification impairs CASR function, and potentiates GPR68 function |
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plays likely a key role in regulating T cell responses during autoimmunity |
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GPR4, GPR68, GPR65, GPR132 are regulators of cell proliferation and migration during tumor growth and wound healing |
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role for GPR68 as a proton sensor that is required for proper enamel formation |
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recognized pH sensor in osteoblasts and osteocytes |