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FLASH GENE
Symbol GPR6 contributors: mct - updated : 24-09-2007
HGNC name G protein-coupled receptor 6
HGNC id 4515
Location 6q21      Physical location : 110.300.297 - 110.301.921
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
SESN1 6q21 sestrin 1 C6orf182 6q21 chromosome 6 open reading frame 182 LOC389422 6 LOC389422 FLJ37396 6q21 hypothetical protein FLJ37396 C6orf184 6q21 chromosome 6 open reading frame 184 LOC345875 6q21 similar to ribosomal protein L7-like 1 C6orf185 6q21 chromosome 6 open reading frame 185 CD164 6q21 CD164 antigen, sialomucin PPIL6 6q21 peptidylprolyl isomerase (cyclophilin)-like 6 SMPD2 6q22.1 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) NICAL 6q21 NEDD9 interacting protein with calponin homology and LIM domains ZNF450 6q22.1 zinc finger protein 450 FLJ25791 6q21 hypothetical protein FLJ25791 LOC389423 6 LOC389423 C6orf199 6q21 chromosome 6 open reading frame 199 KIAA0274 6q21 KIAA0274 GPR6 6q21 G protein-coupled receptor 6 WASF1 6q21-q22 WAS protein family, member 1 CDC40 6q22.1 cell division cycle 40 homolog (yeast) DDO 6q22.1 D-aspartate oxidase SLC22A16 6q22.1 solute carrier family 22 (organic cation transporter), member 16 CDK11 6q22.1 cyclin-dependent kinase (CDC2-like) 11 LOC391959 6 similar to calponin 2; Calonin 2 AMD1 6q21-q22 adenosylmethionine decarboxylase 1 LOC221269 6q22.1 similar to 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
nervousbrainbasal nucleiputamen predominantly
Nervousbrain   specific
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text striatum embryonic kidney (Padmanabhan 2009)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies homolog to murine Gpr6 (94.2 pc)
    intraspecies homolog to GPR3
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text located in the intracellular compartments and is capable of activating Gs-mediated signaling from these compartments (Padmanabhan 2009)
    basic FUNCTION
  • acting as a receptor for the lysosphingolipid sphingosine 1- phosphate (S1P)
  • up-regulates cAMP production in neurons, stimulates neurite outgrowth, and counteracts myelin inhibition (Tanaka 2007)
  • activating a phosphatidylinositol-calcium second messenger system
  • can signal from intracellular compartments (Padmanabhan 2009)
  • may play a role in locomotor and/or reward related behaviors (Padmanabhan 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • palmitate
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS