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FLASH GENE
Symbol GPR55 contributors: mct - updated : 18-08-2011
HGNC name G protein-coupled receptor 55
HGNC id 4511
Location 2q37.1      Physical location : 231.772.043 - 231.789.941
DNA
TYPE functioning gene
STRUCTURE 17.90 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
DNER 2q37.1 delta-notch-like EGF repeat-containing transmembrane TRIP12 2q36.1 thyroid hormone receptor interactor 12 LOC130888 FLJ30794 SP110 2q37.1 SP110 nuclear body protein SP140 2q36.1 SP140 nuclear body protein LOC93349 2q37.1 hypothetical protein BC004921 SP100 2q37.1 nuclear antigen SP100 HMG1L3 2q35 high-mobility group (nonhistone chromosomal) protein 1-like 3 LOC389079 2 similar to tropomyosin 3 LOC391489 2 similar to LOC93349 protein MO25 2q37.1 MO25 protein ITM2C 2q37 integral membrane protein 2C GPR55 2q37 G protein-coupled receptor 55 TSARG1 LOC389080 2 LOC389080 PSMD1 2q37.1-q37.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 HTR2B 2q36.3-q37.1 5-hydroxytryptamine (serotonin) receptor 2B FLJ12584 2q37.1 hypothetical protein FLJ12584 FLJ23510 2q37.1 hypothetical protein FLJ23510 LOC389081 2 LOC389081 B3GNT7 2q36.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 LOC389082 2 similar to archease NCL 2q12-qter nucleolin MGC43122 2q37.1 hypothetical protein MGC43122 GPR66 2q37.1 G protein-coupled receptor 66 LOC391490 2 similar to 60S ribosomal protein L23a MGC35154 2q37.1 hypothetical protein MGC35154 MGC4771 2q37.1 hypothetical protein MGC4771 PTMA 2q36-q36 prothymosin, alpha (gene sequence 28) PDE6D 2q36 phosphodiesterase 6D, cGMP-specific, rod, delta COPS7B 2q36.2 COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) LOC391491 2 similar to guanidinoacetate methyltransferase; GAMT NPPC 2q24-qter natriuretic peptide precursor C MGC42174 2q37.1 hypothetical protein MGC42174 ALPP 2q37.1 alkaline phosphatase, placental (Regan isozyme) ALPPL2 2q37 alkaline phosphatase, placental-like 2 LOC391492 2 similar to xce ALPI 2q37.1 alkaline phosphatase, intestinal ECEL1 2q36-q37 endothelin converting enzyme-like 1 LOC389083 2 similar to enterokinase CHRND 2q37 cholinergic receptor, nicotinic, delta polypeptide
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3828 - 319 - 2007 17765871
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node   highly Homo sapiens
 spleen   highly Homo sapiens
 thymus   highly Homo sapiens
nervousbrainbasal nucleiputamen  
Nervousbrainbasal nucleicaudate nucleus highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
intraspecies homolog to P2RY5,GPR23,GPR35,CCR4
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY signaling , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • receptor for cannabinoids
  • role of GPR55 in bone physiology by regulating osteoclast number and function
  • GPR55 and its endogenous ligand SLC7A7 play essential roles in the homoeostatic responses to stress signals in several mammalian tissues and cells including certain types of immune cells
  • potential role as a receptor for the lysophospholipid lysophosphatidylinositol (LPI, SLC7A7)
  • role of SLC7A7 and its receptor GPR55 in cancer cells in activating an autocrine loop that regulates cell proliferation
  • orphan G protein-coupled receptor that may be engaged by some lipid ligands such as lysophosphatidylinositol and cannabinoid-type compounds
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component DDHD1-SLC7A7-GPR55 axis may be involved in functions in the brain (
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific and functional receptor for lysophosphatidylinositol (SLC7A7)
  • binds a subset of CB1 and CB2 ligands and has been proposed as a cannabinoid receptor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in several prostate and ovarian cancer cell lines, both at the mRNA and at the protein level (it has a critical role in regulating proliferation and anchorage-independent growth)
    Susceptibility to anorexia nervosa
    Variant & Polymorphism other low-functioning Val195 allele of GPR55 appears to be a risk factor for anorexia nervosa
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential therapeutic target
    miscelleaneouspain 
    manipulation of GPR55 may have therapeutic potential in the treatment of both inflammatory and neuropathic pain
    ANIMAL & CELL MODELS