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FLASH GENE
Symbol GPR50 contributors: mct/npt - updated : 05-05-2010
HGNC name G protein-coupled receptor 50
HGNC id 4506
Location Xq28      Physical location : 150.345.055 - 150.349.937
Synonym name melatonin-related receptor
Synonym symbol(s) H9, MGC125342, Mel1c
DNA
TYPE functioning gene
STRUCTURE 4.87 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
IDSP1 Xq28 iduronate 2-sulfatase pseudogene 1 LOC91966 Xq28 hypothetical protein LOC91966 LOC347512 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LW-1 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) FAM11A Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LOC392556 X similar to Melanoma-associated antigen 11 (MAGE-11 antigen) MAGEA11 Xq28 melanoma antigen, family A, 11 MAGEA9 Xq28 melanoma antigen, family A, 9 MAGEA7 Xq28 melanoma antigen, family A, 7, pseudogene MAGEA8 Xq28 melanoma antigen, family A, 8 LOC389900 X similar to DKFZP586L0724 protein LOC389901 X similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) CXorf6 Xq28 chromosome X open reading frame 6 MTM1 Xq28 myotubular myopathy 1 MTMR1 Xq28 myotubularin related protein 1 CD99L2 Xq28 CD99 antigen-like 2 HMGB3 Xq28 high-mobility group box 3 LOC392557 X similar to hypothetical protein GPR50 Xq28 G protein-coupled receptor 50 LOC286456 Xq28 similar to NGFI-A binding protein 1; NGFI-A-binding protein 1; EGR1 binding protein 1 LOC139135 Xq28 hypothetical protein LOC139135 TMG3 Xq28 transmembrane gamma-carboxyglutamic acid protein 3 FATE Xq28 transmembrane gamma-carboxyglutamic acid protein 3 LOC389902 X similar to Cyclic-nucleotide-gated olfactory channel (Cyclic-nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2) (Aorta CNG channel) (RACNG) MAGEA4 Xq28 melanoma antigen, family A, 4 GABRE Xq28 gamma-aminobutyric acid (GABA) A receptor, epsilon LOC392558 X similar to 33K laminin receptor homolog - bovine MAGEA5 Xq28 melanoma antigen, family A, 5 MAGEA10 Xq28 melanoma antigen, family A, 10 GABRA3 Xq28 gamma-aminobutyric acid (GABA) A receptor, alpha 3 GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2020 - 617 - Dufourny (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
 brainmidbraintectum highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor, lacking N-linked glycosylation sites
  • a large C terminus tail
  • HOMOLOGY
    intraspecies homolog to melatonin-related receptor
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • melatonin-related receptor potentially involved in neuroendocrine function
  • playing a role in the regulation of lipid metabolism
  • involvement in mental disorders with links to several disease mechanisms (Grünewald 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors, and specifically inhibits MT1 melatonin receptor function through heterodimerization
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neurite outgrowth inhibitor RTN4 is an interacting partner of GPR50
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased neurite length and filopodia- and lamellipodia-like structures in differentiated Neuroscreen-1 cells (Grünewald 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS