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FLASH GENE
Symbol GPR31 contributors: mct - updated : 15-09-2012
HGNC name G protein-coupled receptor 31
HGNC id 4486
Location 6q27      Physical location : 167.570.360 - 167.571.319
Synonym name
  • 12-(S)-HETE acid receptor
  • 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor
  • hydroxyeicosatetraenoic (HETE) acid receptor 1
    • Synonym symbol(s) 12-HETER, HETER, HETER1
    DNA
    TYPE functioning gene
    STRUCTURE 0.96 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 960 - 319 - 2011 21712392
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines low levels in several cell lines of varied origins
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		seven transmembrane segments (7TM) receptor
    HOMOLOGY
    intraspecies homolog to orphan receptor HM74
    Homologene
    FAMILY G protein coupled receptor family
    CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functions as a critical signaling molecule in the regulation of physiological processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • high affinity recptor for 12-(S)-HETE (12-(S)-hydroxyeicosatetraenoic acid)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    may be dysregulated in several diseases, including malignant megakaryocytes, progressive B-cell chronic lymphocytic leukemia
    constitutional     --other  
    may be dysregulated in arthritis, Alzheimer disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS