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FLASH GENE
Symbol GPR31 contributors: mct - updated : 15-09-2012
HGNC name G protein-coupled receptor 31
HGNC id 4486
Location 6q27      Physical location : 167.570.360 - 167.571.319
Synonym name
  • 12-(S)-HETE acid receptor
  • 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor
  • hydroxyeicosatetraenoic (HETE) acid receptor 1
  • Synonym symbol(s) 12-HETER, HETER, HETER1
    DNA
    TYPE functioning gene
    STRUCTURE 0.96 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    LOC346085 6q27 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) T 6q27 T, brachyury homolog (mouse) MGC35308 6q27 hypothetical protein MGC35308 C6orf83 6q27 chromosome 6 open reading frame 83 BRP44L 6q27 brain protein 44-like RPS6KA2 6q27 ribosomal protein S6 kinase, 90kDa, polypeptide 2 RNASET2 6q27 ribonuclease T2 FGFR1OP 6q27 FGFR1 oncogene partner CCR6 6q27 chemokine (C-C motif) receptor 6 GPR31 6q27 G protein-coupled receptor 31 LOC389448 6 similar to T-complex protein 10A homolog LOC391986 6 similar to unc-93 homolog A UNC93A 6q27 unc-93 homolog A (C. elegans) C6orf104 LOC389449 6 LOC389449 TCP10 6q26 t-complex 10 (mouse) LOC391987 6 similar to Serine palmitoyltransferase 2 (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2) C6orf123 6q27 chromosome 6 open reading frame 123 MLLT4 6q27 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 LOC202546 6q27 hypothetical LOC202546 C6orf54 6q27 chromosome 6 open reading frame 54 KIF25 6q27 kinesin family member 25 FRMD1 6q27 FERM domain containing 1 LOC389450 6 LOC389450 LOC154323 6q27 hypothetical LOC154323 MGC33437 6q27 meningioma expressed antigen 6 (coiled-coil proline-rich) pseudogene DACT2 6q27 dapper homolog 2, antagonist of beta-catenin (xenopus) SMOC2 6q27 SPARC related modular calcium binding 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 960 - 319 - 2011 21712392
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines low levels in several cell lines of varied origins
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    HOMOLOGY
    intraspecies homolog to orphan receptor HM74
    Homologene
    FAMILY G protein coupled receptor family
    CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functions as a critical signaling molecule in the regulation of physiological processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • high affinity recptor for 12-(S)-HETE (12-(S)-hydroxyeicosatetraenoic acid)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    may be dysregulated in several diseases, including malignant megakaryocytes, progressive B-cell chronic lymphocytic leukemia
    constitutional     --other  
    may be dysregulated in arthritis, Alzheimer disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS