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FLASH GENE
Symbol GPR27 contributors: mct - updated : 12-04-2014
HGNC name G protein-coupled receptor 27
HGNC id 4482
Location 3p13      Physical location : 71.803.200 - 71.804.327
Synonym name superconserved receptor expressed in brain 1
Synonym symbol(s) SREB1, GP27
DNA
TYPE functioning gene
STRUCTURE 1.13 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1128 39.7 375 - 2012 2225360
1 - 6185 - 118 - 2012 2225360
1 - 6209 - 118 - 2012 2225360
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
Endocrinepancreas   lowly
Nervousbrainbasal nucleicaudate nucleus  
nervousbrainbasal nucleiputamen  
Nervousbraindiencephalonhypothalamus  
Reproductivefemale systemovary   
 male systemtestis   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains
  • potential N linked glysosylation sites in the N extracellular domain
  • conserved cysteine residues forming disulfide bridge in the first and second extracellular loops
  • HOMOLOGY
    interspecies homolog to rattus Sreb1
    Homologene
    FAMILY
  • rhodopsin family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • is a positive regulator of insulin production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDX1 is important for GPR27 effect on the insulin promoter and insulin secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS