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FLASH GENE

Symbol

GPR27

contributors: mct - updated : 12-04-2014

HGNC name	G protein-coupled receptor 27
HGNC id	4482

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p13      Physical location : 71.803.200 - 71.804.327
Synonym name	superconserved receptor expressed in brain 1
Synonym symbol(s)	SREB1, GP27

DNA

TYPE	functioning gene
STRUCTURE	1.13 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018971 1 - 1128 NP_061844 39.7 375 - 2012 2225360 NM_173359 1 - 6185 NP_775495 - 118 - 2012 2225360 NM_001134649 1 - 6209 NP_001128121 - 118 - 2012 2225360

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine small intestine       Endocrine pancreas       lowly Nervous brain basal nuclei caudate nucleus     nervous brain basal nuclei putamen     Nervous brain diencephalon hypothalamus     Reproductive female system ovary         male system testis         male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane domains
	potential N linked glysosylation sites in the N extracellular domain
	conserved cysteine residues forming disulfide bridge in the first and second extracellular loops

HOMOLOGY

interspecies

homolog to rattus Sreb1

Homologene

FAMILY

rhodopsin family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

is a positive regulator of insulin production

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

PDX1 is important for GPR27 effect on the insulin promoter and insulin secretion

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS