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FLASH GENE
Symbol GPR19 contributors: - updated : 05-07-2006
HGNC name G protein-coupled receptor 19
HGNC id 4473
Location 12p12.3      Physical location : 12.813.994 - 12.849.121
DNA
TYPE anonymous DNA segment
STRUCTURE 35.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - ETV6 - CDKN1B - GPR19 -cen
Authors Montpetit (99)
Physical map
BCLG 12p13-p12 hypothetical protein FLJ33810 LOC387839 12 similar to prothymosin alpha LRP6 12p11.2-p13.3 low density lipoprotein receptor-related protein 6 MORF4LP4 4q1.2 mortality factor 4 like pseudogene 4 FLJ10298 12p13.2 hypothetical protein FLJ10298 LOH12CR1 12p12 loss of heterozygosity, 12, chromosomal region 1 LOC387840 12 LOC387840 DUSP16 12p13-p12 dual specificity phosphatase 16 LOC390296 12 similar to hypothetical protein CREBL2 12p13.2-p13.1 cAMP responsive element binding protein-like 2 GPR19 12p12.3 G protein-coupled receptor 19 CDKN1B 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) DKFZP434F0318 12p13.2 hypothetical protein DKFZp434F0318 DDX47 12p13.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 LOC341465 12p13.2 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) LOC387841 12 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein RAI3 12p13-p12.3 retinoic acid induced 3 GPRC5D 12p13.3 G protein-coupled receptor, family C, group 5, member D HEBP1 12p13.2 heme binding protein 1 LOC387842 12 similar to 5-hydroxytryptamine receptor 7 isoform a; serotonin 5-HT-7 receptor KIAA1467 12p13.2 KIAA1467 protein GSG1 12p13.31 germ cell associated 1 EMP1 12p12.3 epithelial membrane protein 1 FLJ33810 12p13.2 hypothetical protein FLJ33810 GRIN2B 12p12 glutamate receptor, ionotropic, N-methyl D-aspartate 2B
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Hearing/Equilibriumear    
Lymphoid/Immunelymph node    
Nervousbrainbasal nucleicaudate nucleus  
nervousbrainbasal nucleiputamen  
Nervousbraindiencephalonthalamus  
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
intraspecies homolog to D2 dopamine and adregenic receptors,strongly
Homologene
FAMILY G protein coupled receptor family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION may be target of genetic alterations found in several cancers
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in childhood acute lymphoblastic leukemia (ALL)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS