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FLASH GENE

Symbol

GPR182

contributors: npt - updated : 07-05-2004

HGNC name	G protein-coupled receptor 182
HGNC id	13708

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.3-q14      Physical location : 57.388.354 - 57.390.468
Synonym name	adrenomedullin receptor
Synonym symbol(s)	HRHAMR, AMR, 7TMR, ADMR

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     2 Exon(s)

regulatory sequence	Binding site   HRE
text structure	several SP1,AP2,CAAT sites as well as hypoxia-responsive elements (HRE)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D12S1691 - GPR182 - CENTG1 - D12S355 - qter
Authors	GeneMap (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GPR182 2 - 1620 45 404 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart       highly Digestive liver           stomach         Endocrine adrenal gland           pancreas           thyroid         Lymphoid/Immune lymph node         Nervous brain hindbrain medulla oblongata

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Respiratory epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two potential glycosylation sites in the N terminal region
	several serine and threonine cytoplasmic phosphorylation sites

HOMOLOGY

Homologene

FAMILY	adrenomedullin peptide family, members of CGRP
	G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

having rhodopsin-like receptor activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	potential ligand : calcitonin gene related peptide,
	amylin, adrenomedullin peptide family

cell & other

REGULATION

induced by

hypoxia

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS