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FLASH GENE

Symbol

GPR179

contributors: mct - updated : 17-02-2016

HGNC name	G protein-coupled receptor 179
HGNC id	31371

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CSNB1E blindness night congenital, stationary 1E
Location	17q12      Physical location : 36.481.493 - 36.499.693
Synonym name	GPR158-like 1
	probable G-protein coupled receptor 158-like 1
Synonym symbol(s)	GPR158L1

DNA

TYPE	functioning gene
STRUCTURE	18.20 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001004334 11 - 7980 - 2367 - 2005 16229975

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Visual eye retina     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual horizontal association cell Homo sapiens Visual Muller cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a small signal peptide (positions 1–25), the N-terminal extracellular region (position 26-381), with a calcium-binding EGF-like domain (position 278-324)
	the seven transmembrane (7TM)-spanning region (position 382-628)
	the intracellular C-terminal region (position 629-2367), with the presence of a short motif centered on the sequence CPWE, which is repeated at least 22 times in the GPR179-related proteins

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 3 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	possible localization in the outer plexiform layer either in bipolar cells in a cellular compartment distinct from the synaptic membrane and cell body, and/or in horizontal cells, and/or in Müller cell processes as well as within the Müller cell endfeet

basic FUNCTION	is potentially a part of the same transduction pathway and could directly interact withNYX, GRM6, TRPM1
	could be involved in an as-yet unknown interaction between ON-bipolar cells and Müller cells that would be essential for ON-bipolar cell depolarization resulting in b-wave formation
	involved in depolarizing bipolar cell (DBC) function
	role of GPR179 in night vision
	is involved in the ON-bipolar cells (BCs) signaling cascade
	GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	might directly interact with dystrophin isoforms, and its dysfunction would lead to complete CSNB in a similar mechanism as in DMD
	RGS7 is controlled by interaction with two previously uncharacterized orphan GPCRs: GPR158 and GPR179
	GPR179, is required for DBC function and recruits the regulators of G-protein signaling (RGS) proteins, RGS7 and RGS11, to the dendritic tips of the depolarizing bipolar cells (DBCs)
	LRRTM4 is implicated in the GPR179-pikachurin-dystroglycan transsynaptic complex at rod synapses

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CSNB1E

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS