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FLASH GENE
Symbol GPR17 contributors: mct/npt - updated : 19-12-2013
HGNC name G protein-coupled receptor 17
HGNC id 4471
Location 2q14.3      Physical location : 128.403.438 - 128.410.212
Synonym name
  • P2Y-like receptor
  • uracil nucleotide/cysteinyl leukotriene receptor
  • UDP/CysLT receptor
  • Synonym symbol(s) R12, DKFZp686M18273
    DNA
    TYPE functioning gene
    STRUCTURE 6.77 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC150554 2q21.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene GYPC 2q14-q21 glycophorin C (Gerbich blood group) LOC339760 2q21.1 hypothetical LOC339760 BIN1 2q14 bridging integrator 1 LOC389029 2 LOC389029 LOC339761 2q21.1 similar to 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) ERCC3 2q21 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) MAP3K2 2q14.3 mitogen-activated protein kinase kinase kinase 2 LOC389030 2 LOC389030 PROC 2q13-q14 protein C (inactivator of coagulation factors Va and VIIIa) FLJ10006 2q21.1 hypothetical protein FLJ10006 LOC389031 2 similar to myosin-VIIb MYO7B 2q21.1 myosin VIIB LIMS2 2q14.2 LIM and senescent cell antigen-like domains 2 GPR17 2q21 G protein-coupled receptor 17 MGC5391 2q21.1 hypothetical protein MGC5391 FLJ11294 2q21.1 hypothetical protein FLJ11294 POLR2D 2q21 polymerase (RNA) II (DNA directed) polypeptide D MGC4268 2q21 hypothetical protein MGC4268 SAP130 2q21.1 mSin3A-associated protein 130 UGCGL1 2q14.2 UDP-glucose ceramide glucosyltransferase-like 1 HS6ST1 2q21 heparan sulfate 6-O-sulfotransferase 1 LOC391432 2 similar to hypothetical protein LOC389032 2 LOC389032 LOC391433 2 similar to peptidyl-Pro cis trans isomerase LOC391434 2 similar to hypothetical protein DKFZp434P0316
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2315 - 339 - 2008 18533035
    4 - 2609 41 367 - 2008 18533035
    3 - 2544 - 339 - 2008 18533035
    3 - 2380 41 367 - 2008 18533035
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Nervousastrocyte Homo sapiens
    Nervousoligodendrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 7TM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • G potein coupled receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative receptor for purines coupled to G-proteins
  • functions as a potent negative regulator for oligodendrocyte myelination, at least in part, via inducing nuclear localization of differentiation inhibitors ID2 and 4 and opposing OLIG1 function
  • might mediate acute neuronal injury and late microgliosis after focal cerebral ischemia
  • required for initiating the differentiation of oligodendrocyte precursors but has to be down-regulated to allow cells to undergo terminal maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FOXO1 target GPR17 activates AGRP neurons to regulate food intake
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in demyelinating lesions in the CNS
    constitutional     --over  
    in multiple sclerosis plaques
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    inhibiting GPR17 emerges as therapeutic strategy to relieve the oligodendrocyte maturation block and promote myelin repair in MS
    neurologyneurodegenerative 
    may serve as a potential therapeutic target for CNS myelin repair
    neurologyacquired 
    target for neurorepair and are particularly relevant to setting up new therapies for traumatic brain injury (TBI) patients
    ANIMAL & CELL MODELS
    Gpr17 knockout mice showed early onset of oligodendrocyte myelination