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FLASH GENE
Symbol GPR158 contributors: mct - updated : 09-03-2016
HGNC name G protein-coupled receptor 158
HGNC id 23689
Location 10p12.31      Physical location : 25.464.289 - 25.891.155
Synonym name KIAA1136 protein
Synonym symbol(s) KIAA1136
DNA
TYPE functioning gene
STRUCTURE 427.49 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
PILB 10p12 hypothetical protein FLJ14813 LOC143371 10p12.31 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene PTF1A 10p12.31 pancreas specific transcription factor, 1a LOC387642 10 similar to RIKEN cDNA 4921522E24 MGC46732 LOC220213 10p12.31 hypothetical protein LOC220213 DKFZP761L0424 ARHGAP21 10p12.31 Rho GTPase activating protein 21 PRTFDC1 10p12.31 phosphoribosyl transferase domain containing 1 MGC26778 FLJ22002 10p12.31 hypothetical protein FLJ22002 GPR158 10p12.31 G protein-coupled receptor 158 MYO3A 10p11.1 myosin IIIA GAD2 10p11.23 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) APBB1IP 10p12.2 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein LOC387643 10 similar to amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; proline-rich protein 73; Rap1-interacting adaptor molecule TPT 10p12.2-p12.1 trans-prenyltransferase SSH3BP1 10p11.2 spectrin SH3 domain binding protein 1 LOC387644 10 similar to amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; proline-rich protein 73; Rap1-interacting adaptor molecule LOC338616 10p12.1 hypothetical gene supported by AK093172 LOC389944 10 similar to hypothetical protein KIAA1074 10pter-q22.1 KIAA1074 protein YME1L1 10p YME1-like 1 (S. cerevisiae) FLJ14813 10p12.1 hypothetical protein FLJ14813
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 6663 - 1215 - 2013 23451275
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • having a a functional bipartite NLS
  • lacking the ligand binding VFT domain, but it has conserved amino acids involved in G protein binding
  • several phosphorylation sites in the cytoplasmic tail for protein kinases involved in cell cycle progression
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • both endogenous and GC overexpressed GPR158 show an unusual subcellular localization pattern, being found almost entirely in the nucleus
  • plasma membrane GPR158 acts as an anchor for RGS7 complexes, thus may modulate the signaling of other GPCRs
  • basic FUNCTION
  • having metabotropic glutamate, GABA-B-like receptor activity
  • role for elevation of GPR158 expression in glucocorticoid (GC)-induced ocular hypertension
  • essential role for the nuclear translocation in control of cell proliferation
  • is GC-inducible through transcriptional mechanisms in trabecular meshwork (TBM) cells derived from the eye aqueous outflow pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS7 is controlled by interaction with two previously uncharacterized orphan GPCRs: GPR158 and GPR179
  • involvement of CCND1, an important regulator of cell cycle progression from G1 to S phase, in linking nuclear function of GPR158 to cell proliferation
  • GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
  • GPR158 could bind to the RGS7 homo-oligomer without causing its dissociation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of castration-resistant prostate cancer (CRPC)
    ANIMAL & CELL MODELS