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FLASH GENE

Symbol

GPR133

contributors: mct - updated : 13-09-2011

HGNC name	G protein-coupled receptor 133
HGNC id	19893

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q24.33      Physical location : 131.438.451 - 131.626.006
Synonym name	G-protein coupled receptor PGR25
Synonym symbol(s)	PGR25, DKFZp434B1272, MGC138512, MGC138514

DNA

TYPE	functioning gene
STRUCTURE	187.56 kb     25 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198827 25 splicing 5392 Variant 1 96 874 - 2003 12679517 Variant 2 - splicing - Variant 2 - - - 2007 17056209 missing 168 amino acids between GPS & 7tm_2 domains Variant 3 - splicing - Variant 3 - - - 2007 17056209 missing the whole N-ter a frame shift after 7tm_2 domain

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine neuroendocrine pituitary       Homo sapiens Reproductive female system ovary         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a GPS domain
	a PTX domain
	a seven transmembrane region (7tm_2)

HOMOLOGY

interspecies

homolog to murine Gpr133 (80.83 pc)

Homologene

FAMILY	G-protein coupled receptor 2 family, adhesion GPCR subfamily
	LN-TM7 subfamily

CATEGORY

adhesion , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be involved in neuropeptide signaling pathway
	novel gene associated with adult height
	adhesion G-protein-coupled receptor group V, with large genomic size, multiple introns, and a fascinating flora of functional domains
	activates the Gs protein/adenylyl cyclase pathway
	must functionally interact with a G protein to mediate intracellular inositol phosphate formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS