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FLASH GENE
Symbol GPR116 contributors: - updated : 27-03-2007
HGNC name G protein-coupled receptor 116
HGNC id 19030
Location 6p12.3      Physical location : 46.820.241 - 46.922.675
Synonym name KIAA0758 protein
Synonym symbol(s) KIAA0758, KPG_001, FLJ90640
DNA
TYPE functioning gene
STRUCTURE 62.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae) RUNX2 6p21 runt-related transcription factor 2 CLIC5 6p12.1-21.1 chloride intracellular channel 5 ENPP4 6p21.1-p11.2 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function) ENPP5 6p21.1-p11.2 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function) ACTGP9 6p21.1 actin, gamma pseudogene 9 DSCR1L1 6p21-p11 Down syndrome critical region gene 1-like 1 LOC340211 6p21.1 similar to LINE-1 REVERSE TRANSCRIPTASE HOMOLOG CYP39A1 6p21.1-p11.2 cytochrome P450, family 39, subfamily A, polypeptide 1 SLC25A27 6p12.3 solute carrier family 25, member 27 TDRD6 6p21.1 tudor domain containing 6 PLA2G7 6p21.2-p12 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) LOC389394 6 similar to hypothetical protein DKFZp434D2328 MEP1A 6p21.2-p21.1 meprin A, alpha (PABA peptide hydrolase) GPR116 6p12.3 G protein-coupled receptor 116 GPR110 6p21.1 G protein-coupled receptor 110 FLJ22684 6p21.1 hypothetical protein FLJ22684 TNFRSF21 6p21.1-12.2 tumor necrosis factor receptor superfamily, member 21 CD2AP 6p12 CD2-associated protein GPR111 6p12.3 G protein-coupled receptor 111 GPR115 6p12.3 G protein-coupled receptor 115 C6orf138 6p12.3 chromosome 6 open reading frame 138 LOC389395 6 similar to heterogeneous nuclear ribonucleoprotein A3 RBMXP1 6p12.3 RNA binding motif protein, X chromosome pseudogene 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - - - - Bjarnadóttir
  • lacking an Ig-like domain
    • - splicing 5514 149 1346 - -
    - splicing - - - - Bjarnadóttir
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver    
     stomach    
    Endocrinethyroid   highly
    Lymphoid/Immunespleen   highly
    Nervousbraindiencephalonhypothalamus  
    Reproductivemale systemtestis   
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two immunoglobulin-like domain (Ig-like)
  • a seven transmembrane domain (7tm_2)
  • a SEA domain
  • a GPS domain
    • HOMOLOGY
    interspecies homolog to rattus Gpr116 (73.17 pc)
    homolog to murine Gpr116 (72.33 pc)
    Homologene
    FAMILY
  • G protein-coupled receptors family
  • LN-TM7 subfamily
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • may be involved in neuropeptide signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    Dysregulation of protein function: inactivated in renal clear cell carcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS