Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPI contributors: mct - updated : 30-12-2015
HGNC name glucose-6-phosphate isomerase
HGNC id 4458
Corresponding disease
GPID glucose phosphate isomerase deficiency
Location 19q13.11      Physical location : 34.855.644 - 34.893.321
Synonym name
  • glucose phosphate isomerase
  • autocrine motility factor
  • neuroleukin
  • sperm antigen 36
  • oxoisomerase
  • hexose monophosphate isomerase
  • phosphohexomutase
  • Synonym symbol(s) NLK, AMF, PGI, PHI, GNPI, SA36, DKFZp686C13233
    EC.number 5.3.1.9
    DNA
    TYPE functioning gene
    STRUCTURE 42.82 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388532 19 similar to 60S ribosomal protein L21 CHST8 19q13.1 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 KCTD15 19q13.12 potassium channel tetramerisation domain containing 15 LOC390917 19 similar to ribosomal protein S4 LOC126235 19q13.12 similar to ribosomal protein S4, X-linked LOC390918 19 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein DKFZP434D1335 KIAA0355 19q13.12 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein GPI 19q13.1 glucose phosphate isomerase MGC13096 19q13.12 hypothetical protein MGC13096 UBA2 9q12 hypothetical protein MGC13096 LOC126374 19q13.12 similar to LIM domains containing 1 LOC390919 19 similar to ZNF140-like transcription factor LOC390920 19 similar to zinc finger protein 2 ZNF302 19q13.2 zinc finger protein 302 LOC390921 19 similar to Major allergen I polypeptide chain 1 major form precursor (Allergen Fel d 1-A) (Fel d I-A) (Allergen Cat-1) (Fel dI) (AG4) ZNF181 19q13.1-q13.3 zinc finger protein 181 (HHZ181) FLJ30663 19q13.13 hypothetical protein FLJ30663 LOC390922 19 similar to FLJ38451 protein LOC390923 19 similar to zinc finger protein 113 LOC342885 19q13.13 similar to ABO histo-blood group B transferase DKFZp686N19164 FLJ38451 19q13.13 FLJ38451 protein KIAA1533 19q13.13 KIAA1533 SCN1B 19q13.1 sodium channel, voltage-gated, type I, beta HPN 19q13.1 hepsin (transmembrane protease, serine 1) LOC339320 19q13.13 similar to tectorin alpha precursor; Tectorin, alpha FXYD3 19q13.13 FXYD domain containing ion transport regulator 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4275 - 569 - 1995 8530082
    18 - 4212 - 558 - 1995 8530082
    19 - 4356 - 597 - 1995 8530082
    17 - 4125 - 530 - 1995 8530082
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
     thyroid    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland  
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • GPI family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • neurotrophic factor for spinal and sensory neurons
  • involved in glycolysis, gluconeogenesis, energy pathways
  • role in the differentiation and survival of neural stem cells (NSCs)
  • plays a pathophysiologic role in rheumatoid arthritis by stimulating the proliferation, inhibiting the apoptosis, and increasing pro-inflammatory cytokine secretion of fibroblast-like synoviocytes (FLS)
  • AMFR is the cell surface receptor for autocrine motility factor (GPI), which prevents AMFR-dependent mitofusin degradation
  • multifunctional protein that stimulates cell growth and migration, together with its receptor autocrine motility factor receptor (AMFR)
  • promotes cell proliferation and secretion of type II collagen, a marker of proliferating chondrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL6 and Th17 play an essential role in GPI-induced arthritis
  • polyubiquitylation of GPI requires cooperative interaction between AMFR and the ubiquitin ligase TRIM25
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate factor that can be applied in the treatment of cartilage defects
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    B cell depletion reduces the number of autoreactive T helper cells and prevents GPI-induced arthritis
    ANIMAL & CELL MODELS