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FLASH GENE
Symbol GPHA2 contributors: mlc - updated : 15-12-2007
HGNC name glycoprotein hormone alpha 2
HGNC id 18054
Location 11q13.1      Physical location : 64.701.944 - 64.703.360
Synonym name cysteine knot protein
Synonym symbol(s) GPA2, ZSIG51, 2A5B, MGC126572
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure presence of silencer elements upstream and downstream of the promoter
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 774 - 129 - Suzuki (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 pancreas   highly
Reproductivemale systemtestis   
Respiratorylung    
Visualeyeuvea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 23-amino acid signal peptide at its N terminus
  • a potential binding site for the LIM homeodomain transcription factor ISL1
  • 10 cysteine residues likely involved in cystine-knot formation
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family.
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • my be directing the localization of the catalytic enzyme to a particular subcellular compartment
  • may serve as a scaffold for the beta-subunit to activate downstream G protein-mediated signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component two unique subunits, A2 and B5 (heterodimerize to form a novel thyrotrophic hormone, thyrostimulin)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by ISL1 (this protein associates with endocrine systems including the pituitary and pancreas)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS