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FLASH GENE

Symbol

GPER

contributors: mct/npt/pgu - updated : 05-07-2010

HGNC name	G protein-coupled estrogen receptor 1
HGNC id	4485

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p22.3      Physical location : 1.126.442 - 1.133.451
Synonym name	chemokine receptor-like 2
	flow-induced endothelial G-protein coupled receptor
	leucine rich protein in GPR30 3'UTR
	G protein-coupled receptor 30
	lymphocyte-derived G-protein coupled receptor
	IL8-related receptor DRY12
	sex comb on midleg-like protein 2
Synonym symbol(s)	CMKRL2, DRY12, FEG-1, GPCR-Br, LERGU, LERGU2, LyGPR, MGC99678, GPR30, CEPR

DNA

TYPE	functioning gene
STRUCTURE	7.00 kb     3 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	Variants 2, 3 and 4 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - - 2857 54 375 - 1997 9367686 variant 3 - - 2981 54 375 - 1997 9367686 variant 4 - - 2654 54 375 - 1997 9367686

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly   nerve cranial nerve     highly Reproductive female system uterus     highly   female system placenta     highly Skeleton appendicular skeleton lower limbs

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining uroepithelium   highly Homo sapiens Epithelial barrier lining endometrium   highly

cells

System Cell Pubmed Species Stage Rna symbol not specific chondrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

puberty, pregnancy

Text	most abundant in placenta
	in normal cyclic endometrium and early pregnancy decidua

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor family

CATEGORY

receptor G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
text	expressed in the growth plate in infancy and the level of expression declines during pubertal progression (localized to the resting and hypertrophic zones, being absent from the proliferative zone)

basic FUNCTION	intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology
	mediates the nongenomic signaling of 17beta-estradiol (E2) in a variety of estrogen-sensitive cancer cells through activation of the epidermal growth factor receptor (EGFR) pathway
	playing a potential role as a modulator of pubertal growth, and could be involved in the modulation of longitudinal bone growth during puberty
	playing an important role for the inhibitory effect of progestin on cellular growth
	G protein-coupled receptor for estrogen that responds to estrogen with rapid cellular signaling
	indispensable for thymocyte apoptosis that preferentially occurs in T cell receptor beta chain(-/low) double-positive thymocytes
	responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production
	GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased CCND1 by down-regulation of activation protein-1 signaling
	mediate some of the rapid signal transduction events following cell stimulation, such as calcium mobilization and kinase activation, and it also appears to regulate rapid transcriptional activation of genes such as c-fos
	role in estrogen protection against ischaemic stress
	antagonizes growth of ESR1-positive breast cancer
	implicated in rapid non-genomic effects of estrogens
	may have potential functions during sperm migration at midcycle as well as decidualization and blastocyst implantation in the mid-secretory phase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

progestin target gene whose expression correlates with progestin-induced growth inhibition in breast cancer cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast may represent a new target to combat estrogen receptor-positive breast cancer cardiovascular aquired   under cardiac stress exerts direct protection in the heart and may serve as a potential therapeutic target for cardiac drug therapy

ANIMAL & CELL MODELS