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FLASH GENE
Symbol GPER contributors: mct/npt/pgu - updated : 05-07-2010
HGNC name G protein-coupled estrogen receptor 1
HGNC id 4485
Location 7p22.3      Physical location : 1.126.442 - 1.133.451
Synonym name
  • chemokine receptor-like 2
  • flow-induced endothelial G-protein coupled receptor
  • leucine rich protein in GPR30 3'UTR
  • G protein-coupled receptor 30
  • lymphocyte-derived G-protein coupled receptor
  • IL8-related receptor DRY12
  • sex comb on midleg-like protein 2
  • Synonym symbol(s) CMKRL2, DRY12, FEG-1, GPCR-Br, LERGU, LERGU2, LyGPR, MGC99678, GPR30, CEPR
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     3 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 2, 3 and 4 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2857 54 375 - 1997 9367686
    - - 2981 54 375 - 1997 9367686
    - - 2654 54 375 - 1997 9367686
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     nervecranial nerve  highly
    Reproductivefemale systemuterus  highly
     female systemplacenta  highly
    Skeletonappendicular skeletonlower limbs   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier lininguroepithelium highly Homo sapiens
    Epithelialbarrier liningendometrium highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period puberty, pregnancy
    Text
  • most abundant in placenta
  • in normal cyclic endometrium and early pregnancy decidua
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor family
  • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text expressed in the growth plate in infancy and the level of expression declines during pubertal progression (localized to the resting and hypertrophic zones, being absent from the proliferative zone)
    basic FUNCTION
  • intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology
  • mediates the nongenomic signaling of 17beta-estradiol (E2) in a variety of estrogen-sensitive cancer cells through activation of the epidermal growth factor receptor (EGFR) pathway
  • playing a potential role as a modulator of pubertal growth, and could be involved in the modulation of longitudinal bone growth during puberty
  • playing an important role for the inhibitory effect of progestin on cellular growth
  • G protein-coupled receptor for estrogen that responds to estrogen with rapid cellular signaling
  • indispensable for thymocyte apoptosis that preferentially occurs in T cell receptor beta chain(-/low) double-positive thymocytes
  • responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production
  • GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased CCND1 by down-regulation of activation protein-1 signaling
  • mediate some of the rapid signal transduction events following cell stimulation, such as calcium mobilization and kinase activation, and it also appears to regulate rapid transcriptional activation of genes such as c-fos
  • role in estrogen protection against ischaemic stress
  • antagonizes growth of ESR1-positive breast cancer
  • implicated in rapid non-genomic effects of estrogens
  • may have potential functions during sperm migration at midcycle as well as decidualization and blastocyst implantation in the mid-secretory phase
  • endogenous GPER inhibits EDN1-induced vasoconstriction, an effect that may be associated with reduced VSMC Ca(2+) sensitivity)
  • regulates endothelin-dependent vascular tone and intracellular calcium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • progestin target gene whose expression correlates with progestin-induced growth inhibition in breast cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may represent a new target to combat estrogen receptor-positive breast cancer
    cardiovascularaquired 
    under cardiac stress exerts direct protection in the heart and may serve as a potential therapeutic target for cardiac drug therapy
    ANIMAL & CELL MODELS