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FLASH GENE
Symbol GPC1 contributors: mct - updated : 14-10-2011
HGNC name glypican 1
HGNC id 4449
Corresponding disease
DEL2Q37 chromosome 2q subtelomeric deletion syndrome
Location 2q37.3      Physical location : 241.375.114 - 241.407.494
Synonym name
  • glypican proteoglycan 1
    • Synonym symbol(s) FLJ38078, glypican
    DNA
    TYPE functioning gene
    STRUCTURE 32.38 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3686 - 558 - 1999 10364234
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text skeletal system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • thirteen cysteines at conserved position
    • HOMOLOGY
    interspecies homolog to murine Gpc1
    Homologene
    FAMILY glypican family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text anchored to the membrane via a glycosyl phosphatidylinositol anchor
    basic FUNCTION
  • involved in cell adhesion
  • cell growth histogenesis of nervous central system
  • cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family
  • playing plays a role in pancreatic cancer by regulating growth factor responsiveness
  • can regulate Endothelial cells cell cycle progression at least partially by modulating APC/C-mediated degradation of mitotic cyclins and securin
  • playing a possible role in the pathogenesis of Alzheimer disease
  • controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
  • potential role of glypican-1 and possibly other members of the glypican family in prion metabolism
  • acts as a positive regulator of muscle differentiation by sequestering FGF2 in lipid rafts and preventing its binding and dependent signaling
  • appropriate levels of GPC1 are essential for proper regulation of canonical Wnt signaling during differentiation and organization of trigeminal placodal cells into ganglia
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component (heparan sulfate) proteoglycan constituent of integral membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein receptor of SLIT1 and SLIT3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer cell
    tumoral     --over  
    in astrocytoma and oligodendroglioma samples compared with nonneoplastic gliosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS