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FLASH GENE
Symbol GPBAR1 contributors: - updated : 12-07-2007
HGNC name G protein-coupled bile acid receptor 1
HGNC id 19680
Location 2q35      Physical location : 219.125.737 - 219.128.582
Synonym name G-protein coupled bile acid receptor BG37
Synonym symbol(s) BG37, GPR131,GPCR, TGR5, M-BAR, GPCR19
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TNS 2q35-q36 tensin FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein MGC50811 2q35 hypothetical gene supported by BC052750 SLC11A1 2q35 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 CTDSP1 2q35 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 VIL1 2q35 villin 1 USP37 2q35 ubiquitin specific protease 37 RQCD1 2q36.1 RCD1 required for cell differentiation1 homolog (S. pombe) PLCD4 2q35 phospholipase C, delta 4 ZNF142 2q34-q35 zinc finger protein 142 (clone pHZ-49) BCS1L 2q33 BCS1-like (yeast) RNF25 2q36.1 ring finger protein 25 STK36 2q35 serine/threonine kinase 36 (fused homolog, Drosophila) KIAA0173 2p24.3-p24.1 serine/threonine kinase 36 (fused homolog, Drosophila) CYP27A1 2q35-q36 cytochrome P450, family 27, subfamily A, polypeptide 1 PRKAG3 2q35 protein kinase, AMP-activated, gamma 3 non-catalytic subunit LOC391484 2 similar to 60S ribosomal protein L23a WNT6 2q35 wingless-type MMTV integration site family, member 6 WNT10A 2q35 wingless-type MMTV integration site family, member 10A LOC391485 2 similar to cytokeratin 8 CDK5R2 2q35 cyclin-dependent kinase 5, regulatory subunit 2 (p39) HSRNAFEV 2q33 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2023 35 330 - -
  • encoding the same protein than the other variants
  • 2 exons
  • - splicing 1515 35 330 - -
  • encoding the same protein than the other variants
  • 2 exons
  • differing in the 5' UTR compared to variant 1
  • - splicing 1402 35 330 - -
  • encoding the same protein than the other variants
  • 2 exons
  • differing in the 5' UTR compared to variant 1
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestinejejunum  
     intestinesmall intestineileum  
     intestinesmall intestineduodenum  
    digestivelarge intestinececum   
    Digestiveliver    
     stomach    
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
    Nervousnerve   predominantly
    Reproductivefemale systemplacenta  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to chimpanzee GPBAR1 (99.4 pc)
    homolog to murine Gpbar1 (83.8 pc)
    homolog to rattus Gpbar1 (82.4 pc)
    Homologene
    FAMILY G-protein coupled receptor 1 family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • internalized into the cytoplasm in response to bile acids
  • basic FUNCTION
  • responsive activity to bile acids regulates proglucagon gene expression in enteroendocrine cells
  • acting as a receptor for bile acid
  • bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production
  • involved in the suppression of macrophage functions by bile acids
  • acting as a rhodopsin-like receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    bile acids
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS