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FLASH GENE
Symbol GP2 contributors: - updated : 24-07-2006
HGNC name glycoprotein 2 (zymogen granule membrane)
HGNC id 4441
Location 9q21.11-q21.2      Physical location : 20.321.811 - 20.338.835
Synonym name pancreatic zymogen granule membrane associated protein GP2 beta form
Synonym symbol(s) ZAP75
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2100 75 527 - Fukuoka
- splicing - - 380 pancreas Fukuoka
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
Endocrinepancreas    
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveacinar
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zona pellucida-like domain with D8C (domain with conserved eight cysteines in liver-specific ZP domain-containing protein)
  • one EGF-like domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to murine uromodulin
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text zymogen granule membrane
    basic FUNCTION playing a role in regulating membrane trafficking along the apical secretory pathway in pancreatic acinar cells,
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text assembly of vesicular compartment targeted to apical plasma membrane via regulated exocytosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS