Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GORASP2 contributors: mct/npt - updated : 29-11-2015
HGNC name Golgi reassembly stacking protein 2, 55kDa
HGNC id 17500
Location 2q31.1      Physical location : 171.785.710 - 171.823.639
Synonym name Golgi phosphoprotein 6
Synonym symbol(s) GRS2, GOLPH6, GRASP55, FLJ13139, p59, DKFZp434D156
DNA
TYPE functioning gene
STRUCTURE 38.59 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2504 - 452 - 2000 11101516
10 - 2436 - 384 - 2000 11101516
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 mouth   highly
Endocrineadrenal gland   highly
Reproductivefemale systemuterus   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing spinal cord and brain structures
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal GRASP domain, with an unusual arrangement of two tandem PDZ folds that more closely resemble prokaryotic PDZ domains , and is required to tether the Golgi membranes
  • two formin homology domains (FHL1, FHL2)
  • one PDZ/DHR domain
  • two PDZ-like domains followed by a variable C-terminal region
  • HOMOLOGY
    interspecies homolog to murine Gorasp2
    intraspecies paralog to GORASP1
    Homologene
    FAMILY
  • formin homology family
  • cappuccino subfamily
  • GORASP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • localize to the cis and medial-trans cisternae (Xiang 2010)
  • is anchored to the Golgi membranes via myristoylation
  • basic FUNCTION
  • establishing the stacking structure of the Golgi apparatus
  • required for Golgi fragmentation during mitosis and mitotic progression in both yeast and mammalian cells
  • stacks Golgi membranes by forming oligomers through its N-terminal GRASP domain
  • regulates Golgi ribbon formation, and its absence was also sufficient to suppress the requirement for MEK1 in the G2/M transition, a requirement that we previously found depends on an intact Golgi ribbon
  • has no role in the organization of Golgi membranes per se, but it controls their fragmentation by regulating the release of a partner, which requires a G2-specific phosphorylation at T225/T249
  • Golgi matrix proteins having recognized roles in maintaining the architecture of the Golgi complex, in mitotic progression and in unconventional protein secretion
  • having a role in the transport of selected cargo along the conventional secretory pathway
  • may function as an adaptor protein coupling MMP14 with FURIN, thus leading to the activation of the zymogen
  • GORASP1, GORASP2 are required for formation of the Golgi ribbon, a structure which is fragmented in mitosis owing to the phosphorylation of a number of serine and threonine residues situated in its C-terminus
  • GORASP1, GORASP2 are negative regulators of exocytic transport and this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network
  • GORASP1, GORASP2 play a direct and cisternae-specific role in linking ministacks into a continuous membrane network
  • GORASP1, GORASP2 specifically link analogous cisternae to ensure Golgi compartmentalization and proper processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with Rab2 protein
  • tethered to the C terminus of TGFA
  • MMP14 and furin were found to co-localize with Golgi reassembly stacking protein 55 (GORASP2)
  • JAM3 interacted with the Golgi reassembly stacking protein of 55 kDa (GORASP2) in developing germ cells
  • SIRT2 regulates Golgi structure by modulating GORASP2 acetylation levels
  • cell & other
    REGULATION
    Other inhibited in late G2 phase, causing unlinking of the Golgi ribbon
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS