SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
text
| localize to the cis and medial-trans cisternae (Xiang 2010) |
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is anchored to the Golgi membranes via myristoylation |
basic FUNCTION
| establishing the stacking structure of the Golgi apparatus |
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required for Golgi fragmentation during mitosis and mitotic progression in both yeast and mammalian cells |
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stacks Golgi membranes by forming oligomers through its N-terminal GRASP domain |
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regulates Golgi ribbon formation, and its absence was also sufficient to suppress the requirement for MEK1 in the G2/M transition, a requirement that we previously found depends on an intact Golgi ribbon |
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has no role in the organization of Golgi membranes per se, but it controls their fragmentation by regulating the release of a partner, which requires a G2-specific phosphorylation at T225/T249 |
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Golgi matrix proteins having recognized roles in maintaining the architecture of the Golgi complex, in mitotic progression and in unconventional protein secretion |
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having a role in the transport of selected cargo along the conventional secretory pathway |
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may function as an adaptor protein coupling MMP14 with FURIN, thus leading to the activation of the zymogen |
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GORASP1, GORASP2 are required for formation of the Golgi ribbon, a structure which is fragmented in mitosis owing to the phosphorylation of a number of serine and threonine residues situated in its C-terminus |
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GORASP1, GORASP2 are negative regulators of exocytic transport and this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network |
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GORASP1, GORASP2 play a direct and cisternae-specific role in linking ministacks into a continuous membrane network |
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GORASP1, GORASP2 specifically link analogous cisternae to ensure Golgi compartmentalization and proper processing |