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FLASH GENE
Symbol GORAB contributors: mct - updated : 08-07-2019
HGNC name golgin, RAB6-interacting
HGNC id 25676
Corresponding disease
GODP geroderma osteodysplasticum
Location 1q24.2      Physical location : 170.501.262 - 170.522.974
Synonym name
  • NTKL-binding protein 1
  • N-terminal kinase-like-binding protein 1
  • SCY1-like 1 binding protein 1
  • RAB6-interacting golgin
    • Synonym symbol(s) FLJ11752, DUF662.0, NTKLBP1, NTKL-BP1, MGC51263, MGC70512, SCYL1BP1
    DNA
    TYPE functioning gene
    STRUCTURE 21.31 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2583 45 394 - 2008 18997784
    4 - 1718 - 246 - 2008 18997784
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis   
     male systemprostate   
    Skin/Tegumentskin    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two coiled-coil regions, mediating protein–protein interaction
  • a bipartite nuclear localization signal
  • several putative phosphorylation sites
    • HOMOLOGY
    intraspecies homolog to NTKL
    Homologene
    FAMILY
  • NTKLBP1 family
  • GORAB family
  • golgin protein family
    • CATEGORY secretory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text localized to the Golgi apparatus
    basic FUNCTION
  • involved in the secretory pathway
  • promoted MDM2 degradation through proteasome pathway by stimulating its self-ubiquitination
  • regulator of the MDM2-TP53 feedback loop and it may be a potential tumor suppressor
  • is a novel transcriptional activator in neurite outgrowth by directly modulating the MDM2/TP53-dependent pathway, which might play an important role in CNS development and axonal regeneration after injury
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RCHY1 enhances or represses the ubiquitin-protein ligase activity of RCHY1
  • specific interaction with RAB6A
  • binds to a TP53-induced protein, TP53-induced RCHY1
  • by interaction with MDM2, promoted MDM2 self-ubiquitination and induced MDM2 protein degradation
  • GORAB can directly induce MDM2 transcription, whereas inhibiting the function of MDM2 by specific small interfering RNAs results in partial rescue of neurite outgrowth and neuronal morphogenesis defects induced by GORAB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GODP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS