protein
| the C terminus of CFTR (binding) with TC10 (to signaling pathway) |
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frizzled (FDZ6, FDZ8) |
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colocalising and interacting with GOLGA3 (isoform specific) |
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interact with syntaxin 6, a Q-SNARE protein that is involved in trafficking between endosomes and the trans-golgi network |
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interacts with CSPG5(this interaction may play a role in the intracellular transport of CSPG5/neuroglycan) |
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binding partner for Rho effector Rhotekin (RTKN) (involvement of GOPC in the recruitment of Rhotekin to adherens junctions and playing a possible role in cell-polarity development and/or maintenance) |
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ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis |
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binding partner of GRM1, through its PSD95/discslarge/ZO1 homology domain |
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with BICD2 and DCTN1, interacting with RAB6A |
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STX6 is a new component of the GOPC complex that regulates the abundance and function of CFTR at the post-ER level |
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interacting with GRM5 (its protein expression may be regulated at the post-translational level by the GOPC protein, possibly by blocking ubiquitination-dependent receptor degradation) |
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in trans-Golgi network (TGN), SLC34A1 interacts with GOPC (PDZ-domain protein interacting specifically with TC10), a TGN-resident PDZ-domain-containing protein |
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ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins GOPC and STX6 |
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trans-Golgi-associated protein that interacts through its single PDZ domain with a variety of cell surface receptors |
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colocalizes with SNX1 and the internalized ADRB1 and protects endocytosed receptors from lysosomal degradation |
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TNF regulates GRID2 gene expression by activating CDC42 and GOPC genes |
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GOPC, a Golgi-associated, PDZ domain-containing protein, interacts with PCDH15 |