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FLASH GENE
Symbol GOPC contributors: mct - updated : 05-09-2015
HGNC name golgi associated PDZ and coiled-coil motif containing
HGNC id 17643
Location 6q22.1      Physical location : 117.881.434 - 117.923.705
Synonym name
  • PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10
  • fused in glioblastoma
  • golgi associated PDZ and coiled-coil motif containing
  • CFTR-associated ligand
  • Synonym symbol(s) CAL, FIG, PIST, GOPC1, dJ94G16.2
    DNA
    TYPE functioning gene
    STRUCTURE 42.27 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4640 50 462 - 2007 17158866
    8 - 4616 49 454 - 2007 17158866
    lacking an in-frame exon
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain with a specific interaction with the C-terminal peptide of NLGN1
  • one leucine zipper
  • two coiled coil regions
  • mono polymer homomer , dimer , polymer
    HOMOLOGY
    interspecies homolog to murine Pist
    Homologene
    FAMILY
    CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,Golgi
    text
  • Golgi stack
  • trans-Golgi-associated protein
  • basic FUNCTION
  • playing a role in the vesicle transport of frizzled from the Golgi apparatus to the plasma membrane
  • involved in membrane vesicle trafficking
  • might be a general sorting molecule that assists membrane–receptor trafficking
  • mediates lysosomal trafficking and degradation of CFTR
  • having a negative effect on apical-membrane expression levels of the most common disease-associated mutant deltaF508-CFTR
  • contributes to the fine-tuning of ADRB1 sorting both during biosynthetic and postendocytic trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the C terminus of CFTR (binding) with TC10 (to signaling pathway)
  • frizzled (FDZ6, FDZ8)
  • colocalising and interacting with GOLGA3 (isoform specific)
  • interact with syntaxin 6, a Q-SNARE protein that is involved in trafficking between endosomes and the trans-golgi network
  • interacts with CSPG5(this interaction may play a role in the intracellular transport of CSPG5/neuroglycan)
  • binding partner for Rho effector Rhotekin (RTKN) (involvement of GOPC in the recruitment of Rhotekin to adherens junctions and playing a possible role in cell-polarity development and/or maintenance)
  • ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis
  • binding partner of GRM1, through its PSD95/discslarge/ZO1 homology domain
  • with BICD2 and DCTN1, interacting with RAB6A
  • STX6 is a new component of the GOPC complex that regulates the abundance and function of CFTR at the post-ER level
  • interacting with GRM5 (its protein expression may be regulated at the post-translational level by the GOPC protein, possibly by blocking ubiquitination-dependent receptor degradation)
  • in trans-Golgi network (TGN), SLC34A1 interacts with GOPC (PDZ-domain protein interacting specifically with TC10), a TGN-resident PDZ-domain-containing protein
  • ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins GOPC and STX6
  • trans-Golgi-associated protein that interacts through its single PDZ domain with a variety of cell surface receptors
  • colocalizes with SNX1 and the internalized ADRB1 and protects endocytosed receptors from lysosomal degradation
  • TNF regulates GRID2 gene expression by activating CDC42 and GOPC genes
  • GOPC, a Golgi-associated, PDZ domain-containing protein, interacts with PCDH15
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion   protein chimeric
    interstitial del(6)(q21q21) chimeric protein GOPC/ROS1 in a glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    candidate target for the treatment of CF (PMID: 21543871)
    ANIMAL & CELL MODELS