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FLASH GENE
Symbol GOLIM4 contributors: mct/npt - updated : 25-11-2009
HGNC name Golgi integral membrane protein 4
HGNC id 15448
Location 3q26.2      Physical location : 167.727.653 - 167.813.417
Synonym name
  • Golgi phosphoprotein 4
  • Golgi-localized phosphoprotein of 130 kDa
  • Golgi phosphoprotein of 130 kDa
  • cis Golgi-localized calcium-binding protein
  • Synonym symbol(s) GIMPC,GPP130, GOLPH4, P138
    DNA
    TYPE functioning gene
    STRUCTURE 85.00 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2838 81 696 - Starr (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short N terminal cytoplasmic tail
  • a protein kinase C phosphorylation site
  • a myristoylation site
  • a membrane spanning segment
  • a large C terminal acidic lumenal domain
  • a potential N glycosylation site
  • an O-glycosylation site
  • multiple phosphorylation sites
  • a putative leucine zipper
  • a large number of heptad repeats predicted to participate in coiled-coil dimer formation
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • GOLIM4 family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • Golgi membrane phosphorylation type II
  • localized in the early Golgi (CIS-and/or medial-Golgi resident protein)
  • Golgi-resident protein based on its perinuclear co-localization with TMEM115 (Ivanova 2008)
  • basic FUNCTION
  • modifying proteins and lipids in the secretory pathway
  • golgi targeting information
  • Golgi protein containing stem domain Golgi targeting determinants, cycle to the cell surface and back along the late endosome independent TGN38/46 pathway (Puri 2002)
  • undergoes endosome-to-Golgi retrieval using the late endosome-bypass pathway in nonpolarized cells, cycles via the basolateral membrane in polarized MDCK cells (Puthenveedu 2003)
  • integral membrane protein retrieved via the bypass pathway from endosomes to its steady-state location in the cis-Golgi (Natarajan 2004)
  • required for efficient exit of Shiga toxin B-fragment from endosomes en route to the Golgi apparatus (Natarajan 2004)
  • cis Golgi protein, representative of proteins cycling between the Golgi apparatus and endosomes in a pH-sensitive manner (Starr 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text
  • endocytotic transport vesicle
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS