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FLASH GENE
Symbol GOLGB1 contributors: mct/npt/pgu - updated : 13-05-2009
HGNC name golgin B1, golgi integral membrane protein
HGNC id 4429
Location 3q13.33      Physical location : 121.382.049 - 121.468.602
Synonym name
  • giantin/macrogolgin
  • golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1
  • golgi integral membrane protein 1
  • 372 kDa golgi complex-associated protein
  • Synonym symbol(s) GCP, GCP372, giantin, GOLIM1
    DNA
    TYPE functioning gene
    STRUCTURE 86.55 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 11185 376 3259 - 2001 11590181
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha helical domains with heptad repeats that can form coiled-coils
  • a transmembrane segment and a long cytoplasmic domain
  • HOMOLOGY
    interspecies homolog to murine Golgb1
    Homologene
    FAMILY
  • GEARS family
  • golgin subfamily B
  • CATEGORY structural protein , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text in the mutants, abnormally localized in the endoplasmic reticulum and degraded by proteasomes
    basic FUNCTION
  • potentially participating in forming the intercisternal cross-bridges of the Golgi complex
  • required for the delivey of cargo proteins to Golgi apparatus
  • COG-sensitive, integral membrane Golgi protein, whose abundance is regulated by COG and COPI complexes
  • may modulate the flow patterns within the Golgi stack
  • with GOLGA2, and GORASP1, facilitates vesicle fusion to the Golgi membrane as a vesicle "tethering factor"
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text golgi biogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GCP60 (GOLPH1)
  • interacting with USO1
  • interacts with both the small GTPase RAB6A, RAB6B, RAB6C and RAB1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene autoantigen in rheumatoid arthritis
    Marker
    Therapy target
    ANIMAL & CELL MODELS