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FLASH GENE
Symbol GOLGA5 contributors: mct/npt - updated : 25-09-2020
HGNC name golgi autoantigen, golgin subfamily a, 5
HGNC id 4428
Location 14q32.12      Physical location : 93.260.649 - 93.306.304
Synonym name
  • golgin 84
  • RET-fused gene 5 protein
  • golgi integral membrane protein 5
  • Ret-II protein
  • Synonym symbol(s) RET2, ret-II, golgin-84, rfg5, GOLIM5, PTC5
    DNA
    TYPE functioning gene
    STRUCTURE 45.65 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2879 82.9 731 - 2010 20874812
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic coiled coil
  • a proto RET kinase domain
  • a single transmembrane segment close to its C terminus
  • HOMOLOGY
    Homologene
    FAMILY Golgin subfamily
    CATEGORY antigen , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • plays a key role in the assembly and maintenance of the Golgi ribbon in mammalian cells
  • involved in generating and maintaining the architecture of the Golgi apparatus
  • may modulate the flow patterns within the Golgi stack (Malsam 2005)
  • functions as a tethering factor for coat protein I (COPI) vesicles
  • is a gene significantly down-regulated in eosinophils
  • encodes a coiled-coil protein localized to the Golgi surface, and may play a role in vesicle tethering and docking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming the RET-II oncogene when fused by its coiled coil domain to the RET tyrosine kinase domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of GOLGA5 with COG complex plays likely an important role in the tethering process of intra-Golgi retrograde vesicle traffic
  • GOLGA5-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of CDKN5 and extracellular signal-regulated kinase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS