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FLASH GENE
Symbol GOLGA3 contributors: mct/npt - updated : 06/11/2008
HGNC name golgi autoantigen, golgin subfamily a, 3
HGNC id 4426
Location 12q24.33      Physical location : 133.345.494 - 133.405.426
Synonym name
  • golgin 160
  • male enhanced antigen-2
  • SY2/SY10 protein
  • Golgi complex-associated protein of 170 kD
  • Synonym symbol(s) SY2/SY10, GCP170, MEA2
    DNA
    TYPE functioning gene
    STRUCTURE 59.80 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 9252 167 1498 - Hicks (2006)
    unable to bind GOPC
    - - 5070 155 1390 - Hicks (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus    
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • intermediate filament long coiled coil domain
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GD) called the GRID domain
  • HOMOLOGY
    interspecies homolog to murine Golga3
    Homologene
    FAMILY
  • ezrin/radixin/moesin family
  • golgin subfamily
  • CATEGORY structural protein , antigen , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text localized to the Golgi cisternae distinct from the trans-Golgi network (TGN)
    basic FUNCTION
  • involved in RAB6 regulated membrane tethering events
  • required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes
  • peripheral Golgi membrane protein that is important for transduction of certain pro-apoptotic signals at the Golgi complex
  • plays an important role in directing insulin-regulated trafficking proteins toward the insulin-responsive compartment in adipocytes
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • Golgi complex antigen targeted to autoantibodies associated with Sjögren syndrome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6
  • TSNAX
  • cleaved by caspases during apoptosis
  • interacting with GLUT4
  • interacts with ADRB1 (between the head of golgin-160 and the third intracellular loop of ADRB1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS