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FLASH GENE
Symbol GOLGA1 contributors: mct - updated : 03-03-2015
HGNC name golgi autoantigen, golgin subfamily a, 1
HGNC id 4424
Location 9q33.3      Physical location : 127.640.573 - 127.703.386
Synonym name
  • golgin-97
  • gap junction protein, alpha 4, 37kD
  • Synonym symbol(s) golgin-97
    DNA
    TYPE functioning gene
    STRUCTURE 62.81 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text nine alternative transcripts encoding 9 distincts proteins (ACE/NCBI)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 4899 - 767 - 2003 15269279
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large coiled coil domain
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GLD) called the GRIP domain, and GRIP domains of GOLGA4 and GOLGA1 bind discriminately to distinct membrane subdomains of the TGN
  • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/radixin/moesin family
  • golgin family
  • CATEGORY antigen , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • GOLGA1, GOLGA4 are targeted to the Golgi membrane through their GRIP domains
  • basic FUNCTION
  • involved in RAB6 regulated membrane-tethering events
  • GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
  • selective and essential component of the tubulovesicular carriers transporting CDH1 out of the TGN
  • may be involved in the maturation of the virus core and, potentially, the virus membrane
  • trans-Golgi network membrane protein, essential for virus replication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • Golgi complex antigen targeted by autoantibodies associated with Sjögren syndrome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARL1 through GRIP domain
  • interaction between RAB2A and the ARL1-regulated scaffolding proteins GOLGA4 and GOLGA1 might be necessary for RAB2A to be released from the Golgi for further vesicular trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS