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FLASH GENE
Symbol GNRH1 contributors: mct/npt/pgu - updated : 29-10-2016
HGNC name gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HGNC id 4419
Corresponding disease
FIGD gonadotropin deficiency, familial idiopathic
Location 8p21.2      Physical location : 25.276.775 - 25.282.556
Synonym name
  • gonadotropin-releasing hormone 1
  • progonadoliberin I
    • Synonym symbol(s) LHRH1, GNRH, GRH, LHRH, LNRH
    DNA
    TYPE functioning gene
    STRUCTURE 5.78 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure two DNA binding sites for the POU class of transcriptions factor interacting with the proteins Brn-2 and Oct-1 (Brn-2 increased promoter activity)
    MAPPING cloned Y linked Y status provisional
    Map pter - GNRH1 - NRG1 - ADRB3 ADRB3 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2166 - 92 - 2009 19567835
    4 - 1297 - 92 - 2009 19567835
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
     brainmidbrain   
    Reproductivemale systemprostate  highly
     male systemtestis   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing teeth
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • decapeptide
    • HOMOLOGY
    Homologene
    FAMILY
  • GnRH family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • gonadotropin releasing hormone 1, releasing form, activating pituitary gonadotropin production
  • including a GNRH-associated peptide
  • involved in the regulation of reproduction
  • capable of eliciting their biological actions in an autocrine and/or paracrine manner within and between these maternal and fetal cellular compartments
  • GNRH1 and activin A synergistically regulate human FSHB subunit transcription
  • master hormone of the reproductive endocrine system
  • inducer of CDH1 to CDH3 switching, which is a crucial step during tumorigenesis and metastasis, overexpression ofCDH3 significantly enhancing migration and invasion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • action of GNRH1 in the regulation of gonadotropin subunit expression is enhanced by the presence of ADCYAP1R1
  • expression of BRMS1L depends on CTNNB1 activity and contributes to FSHB induction by GNRH1
  • GNRH1 augments the ability of ADCYAP1 to regulate gonadotrope function by increasing pituitary ADCYAP1 and PACAP receptor expression
  • TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
  • regulation of HOMER1 splicing by GNRH1 contributes to gonadotropin gene control
  • SEMA3E is an essential gene for GNRH1 neuron development
  • KISS1 regulates reproduction by stimulating GNRH1 secretion
  • IRF2BPL expression critically regulates puberty as well as GNRH1 expression
  • RNF216 regulates the migration of GNRH1 neuron by suppressing BECN1 mediated autophagy, suggesting a potential contribution of autophagy to the hypogonadotropic hypogonadism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FIGD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • promotes tumor cell migration and invasion in ovarian cancer through CDH3 to CDH1 switching and CTNND1 activation
    • Marker
    Therapy target
    ANIMAL & CELL MODELS