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FLASH GENE
Symbol GNG5 contributors: - updated : 13-02-2006
HGNC name guanine nucleotide binding protein (G protein), gamma 5
HGNC id 4408
Location 1p22      Physical location : 84.964.006 - 84.972.262
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ23033 1p22.3 hypothetical protein FLJ23033 PRKACB 1p36.1or protein kinase, cAMP-dependent, catalytic, beta LOC148418 1p22.3 dnaj-like protein LOC391051 1 similar to urate oxidase (EC 1.7.3.3) - baboon DLAD 1p31.1 similar to urate oxidase (EC 1.7.3.3) - baboon RPF1 1p22.3 similar to urate oxidase (EC 1.7.3.3) - baboon GNG5 1p22 guanine nucleotide binding protein (G protein), gamma 5 SPATA1 1p22.3 spermatogenesis associated 1 CTBS 1p22 chitobiase, di-N-acetyl- FLJ35487 1p22.3 hypothetical protein FLJ35487 SSX2IP 1p22 synovial sarcoma, X breakpoint 2 interacting protein EDG7 1p22.3-p31.1 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 MCOLN2 1p22 mucolipin 2 MCOLN3 1p22.3 mucolipin 3 NYD-SP29 1p22.3 testis development protein NYD-SP29 FLJ13815 1p22.3 hypothetical protein FLJ13815 gm117 1p22.3 gm117 BCL10 1p22 B-cell CLL/lymphoma 10 DDAH1 1p22 dimethylarginine dimethylaminohydrolase 1 CYR61 1p31.p22 cysteine-rich, angiogenic inducer, 61 FLJ20729 1p22.3 hypothetical protein FLJ20729 COL24A1 1p22.3-p22.2 collagen, type XXIV, alpha 1 KIAA1229 1p22.3 KIAA1229 protein
RNA
TRANSCRIPTS type messenger
text with alternative transcriptional star sites resulting from two separate,closely linked 5' promoters (Liu)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
mono polymer heteromer , trimer
HOMOLOGY
interspecies ortholog to murine Gng5
homolog to Xenopus Xl.7680
homolog to zebrafish Dr.9659
homolog to C.elegans K02A4.2
Homologene
FAMILY G protein gamma family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • modulating or transducing various transmembrane signaling systems
  • required for the GTPase activity and for the replacement of GDP by GTP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterotrimeric G-protein GTPase, gamma-subunit
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GDP, GTP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS