Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GNG4 contributors: mct - updated : 28-03-2017
HGNC name guanine nucleotide binding protein (G protein), gamma 4
HGNC id 4407
Location 1q42.3      Physical location : 235.710.986 - 235.814.054
Synonym name
  • guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  • guanine nucleotide binding protein 4
  • Synonym symbol(s) GNGT4, DKFZp547K1018, FLJ23803, FLJ34187, IG, SG
    DNA
    TYPE functioning gene
    STRUCTURE 103.07 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KCNK1 1q42-q43 potassium channel, subfamily K, member 1 SLC35F3 1q42.3 solute carrier family 35, member F3 LOC148640 1q42.3 similar to ribosomal protein S15 LOC388753 1 similar to RIKEN cDNA 1810063B05 TARBP1 1q42.3 TAR (HIV) RNA binding protein 1 IRF2BP2 1q42.3 interferon regulatory factor 2 binding protein 2 LOC284527 1q42.3 hypothetical gene supported by BC016972 TOMM20 1q42 hypothetical gene supported by BC016972 KIAA0117 1q42.3 KIAA0117 protein RBP1L1 1q42.1-q43 retinoblastoma binding protein 1-like 1 GGPS1 1q43 geranylgeranyl diphosphate synthase 1 TBCE 1q42.3 tubulin-specific chaperone e MGC39558 1q42.3 hypothetical protein MGC39558 GNG4 1q42.3 guanine nucleotide binding protein (G protein), gamma 4 CHS1 1q42.1-q42.2 Chediak-Higashi syndrome 1 NID 1q43 nidogen (enactin) LOC343508 1q42.3 similar to aconitase 2 TM7SF1 1q42-q43 transmembrane 7 superfamily member 1 (upregulated in kidney) ERO1LB 1q42.2-q43 ERO1-like beta (S. cerevisiae) EDARADD 1q42.3 EDAR-associated death domain ENO1P 1q41-q42 enolase 1, (alpha) pseudogene LGALS8 1q42-q43 lectin, galactoside-binding, soluble, 8 (galectin 8) FLJ10359 1q42.3 protein BAP28 ACTN2 1q42-q43 actinin, alpha 2 MTR 1q43 5-methyltetrahydrofolate-homocysteine methyltransferase LOC388754 1 similar to 60S ribosomal protein L35 RYR2 1q42.1-q43 ryanodine receptor 2 (cardiac)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4997 8.4 75 - 1995 7665596
    4 - 5123 8.4 75 - 1995 7665596
    3 - 4885 8.4 75 - 1995 7665596
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GGL domain
  • secondary structure alpha, beta, gamma subunit
    HOMOLOGY
    interspecies homolog to gng4
    Homologene
    FAMILY
  • G protein gamma family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • gamma subunit of the G protein complex, having the potential to negatively regulate signaling downstream of oncogenic GPCRs
  • GNG4 indeed is a potential tumor suppressor in glioblastoma (GBM)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C terminus of GNG4 showed strong interaction with KCNK2, whereas N terminus did not
  • GNG4 is an inhibitor of CXCL12/CXCR4-dependent signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in mesenchymal glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS