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Symbol GNAZ contributors: npt/mct - updated : 18-01-2006
HGNC name guanine nucleotide binding protein (G protein), alpha z polypeptide
HGNC id 4395
Location 22q11.22      Physical location : 23.412.668 - 23.467.221
Synonym name
  • transducin alpha
  • G(x) alpha chain
  • Synonym symbol(s) Gz-alpha, Galphaz
    DNA
    TYPE functioning gene
    STRUCTURE 54.56 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    RTDR1 22q11.2 rhabdoid tumor deletion region gene 1 GNAZ 22q11.22 guanine nucleotide binding protein (G protein), alpha z polypeptide
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3225 41 355 - Dutt (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GTPase domain made of three regions named switches 1,2 and 3
  • sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • lacking a pertussis modification site
  • conjugated LipoP , Other
    HOMOLOGY
    interspecies ortholog to murine Gnaz
    homolog to C.elegans gpa-16
    Homologene
    FAMILY
  • G-alpha family
  • subfamily 1 (G(I/O/T/Z))
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction in pertussis toxin-insensitive systms
  • playing a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids
  • involved as modulators or transducers in various transmembrane signaling systems
  • inhibits serum response factor-dependent transcription by inhibiting Rho signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of PTX insensitive heterotrimeric G-protein complexes
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein interacting with RGS20
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS