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FLASH GENE
Symbol GNAI1 contributors: mct/npt - updated : 11-04-2015
HGNC name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HGNC id 4384
Location 7q21.3-q22.1      Physical location : 79.764.139 - 79.848.725
Synonym name Gi1 protein alpha subunit
Synonym symbol(s) GI
DNA
TYPE functioning gene
STRUCTURE 84.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3318 - 354 - Lyssand (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • guanine nucleotide-binding protein having alpha inhibiting activity
  • are involved as modulators or transducers in various
  • transmembrane signaling systems
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • interaction with RGS14 (selective interactions between GNAI1, GNAI3 and the GoLoco domain of RGS14 influence its dynamic subcellular localization) (
  • links GNAI1 proteins to inhibit GNAQ-induced RAS/ERK1/2 activation
  • is a GTPase-activating protein for the GNAQ and GNAI1 subunits of heterotrimeric G-proteins that turns off signaling by G-protein coupled receptors
  • GAP43 is involved in the orientation of cell division by interacting with GNAI1 and this should be an important mechanism for neurogenesis in the mammalian brain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    being a critical factor leading to cellular electrophysiological remodeling and cardiac arrhythmias in hypertrophic cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS