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FLASH GENE
Symbol GNA15 contributors: mct - updated : 21-09-2016
HGNC name guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HGNC id 4383
Location 19p13.3      Physical location : 3.136.190 - 3.163.766
Synonym symbol(s) GNA16
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC360200  polyserase 1 TIMM13 19p13.3 translocase of inner mitochondrial membrane 13 homolog (yeast) LMNB2 19p13.3 lamin B2 GADD45B 19p13.3 growth arrest and DNA-damage-inducible, beta FLJ00058 19p13.3 hypothetical protein FLJ00058 GNG7 19p13.3 guanine nucleotide binding protein (G protein), gamma 7 LOC390875 19 similar to fos39347_1 DIRAS1 19p13.3 DIRAS family, GTP-binding RAS-like 1 LOC388490 19 LOC388490 SLC39A3 19p13.3 solute carrier family 39 (zinc transporter), member 3 SGTA 19p13 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha THOP1 19p13.3 thimet oligopeptidase 1 FLJ34817 19p13.3 hypothetical protein FLJ34817 MGC26707 19p13.3 hypothetical protein MGC26707 FLJ11637 19p13.3 hypothetical protein FLJ11637 LOC126295 19p13.3 hypothetical protein LOC126295 ZNF77 19p zinc finger protein 77 (pT1) FLJ14009 19p13.3 transducin-like enhancer protein 6 TLE2 19p13.3 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) AES 19p13.3 amino-terminal enhancer of split GNA11 19p13.3 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) LOC390876 19 similar to ribosomal protein L35 GNA15 19p13.3 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) LOC388491 19 similar to KIAA1683 protein EDG6 19p13.3 endothelial differentiation, G-protein-coupled receptor 6 LOC56926 19p13.3 hypothetical protein from EUROIMAGE 2021883 BRUNOL5 19p13 bruno-like 5, RNA binding protein (Drosophila) NFIC 19p13.3 nuclear factor I/C (CCAAT-binding transcription factor) LOC284422 19p13.3 similar to HSPC323 MGC4293 19p13.3 hypothetical protein MGC4293 FZR1 19p13.3 hypothetical protein MGC4293 LOC388492 19 LOC388492 MGC20700 19p13.3 hypothetical protein MGC20700 HMG20B 19p13.3 high-mobility group 20B GIPC3 19p13.3 PDZ domain protein GIPC3 LOC388493 19 similar to putative protein (5J182) TBXA2R 19p13.3 thromboxane A2 receptor PIP5K1C 19p13.3 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma TJP3 19p13.3 tight junction protein 3 (zona occludens 3)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 salivary gland   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemovary  highly
 male systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain with three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • beta3 region of GNA16 is essential for interaction with TTC1 and the subsequent activation of RAS, but has relatively minor influence on the PLCB1 interaction
  • HOMOLOGY
    Homologene
    FAMILY G-alpha family, G(q) subfamily
    CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle
    basic FUNCTION
  • mediating pertussis toxin-resistant stimulation of phospholipase C beta
  • involved as modulators or transducers in various
  • transmembrane signaling systems
  • GNA15 regulates multiple signaling pathways by activating RAS through its association with TTC1, but TTC1 is not required for GNA15 to stimulate PLCB1
  • may utilize different structural domains to bind TTC1 and PLCB1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • GNA15 associate with tetratricopeptide repeat 1 (TTC1), an adaptor protein which preferentially binds to RAS
  • GNA15 can signal through TTC1/RAS and PLCB1 simultaneously and independently
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS