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FLASH GENE

Symbol

GNA14

contributors: mct - updated : 19-09-2016

HGNC name	guanine nucleotide binding protein (G protein), alpha 14
HGNC id	4382

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q21.2      Physical location : 80.037.995 - 80.263.232
Synonym name	G-protein alpha subunit 14

DNA

TYPE	functioning gene
STRUCTURE	225.24 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - GNAQ - GNA14 - D9S1674 - D9S153 - D9S1780 - D9S1867 - D9S1843 - qter
Authors	Rubio (99)

regionally located

GNA14 and GNAQ are in a head to tail arrangement

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004297 7 - 2492 NP_004288 41.6 355 - 1999 10191087

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	GTPase domain made of three regions named switches 1,2 and 3 and including the sites for guanine nucleotide binding and effector interaction
	an helical domain

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to murine Gna14
	homolog to C.elegans mo1d7.7

Homologene

FAMILY	G-alpha family
	G(q) subfamily

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular

basic FUNCTION	mediating pertussis toxin-resistant stimulation of phospholipase C beta
	cell fate specification
	palmitoylated at distinct polycysteine sequences, and the adjacent polybasic domain is not required for Galpha palmitoylation but is important for localization and functional activity of heterotrimeric G proteins
	GNA12 and GNA14 play a key role in the genetic architecture underlying normal gray matter density (GMD) variation in frontal and parietal regions
	GNA11 and GNA14 induce changes in cellular morphology and growth-factor independence via MAPK activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

heterotrimeric G protein GTPase, alpha subunit

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	beta and gamma subunits of the trimeric G protein
	TTC1 is required for GNA14 to stimulate RAS-dependent signaling pathways, but not for the propagation of signals along RAS-independent pathways
	previously identified PLCB1-interacting AAs are insufficient to ensure productive interaction of GNA14 with PLCB1, while an intact N-terminal half of GNA14 is apparently required for PLCB1 interaction

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008) tumoral somatic mutation       in congenital tufted angiomas (TAs), kaposiform hemangioendotheliomas (KHEs), and childhood lobular capillary hemangiomas (LCHs) constitutional     --over   severe preeclamptic (sPE) human placentas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS