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FLASH GENE
Symbol GNA13 contributors: mct - updated : 06-04-2013
HGNC name guanine nucleotide binding protein (G protein), alpha 13
HGNC id 4381
Location 17q24.1      Physical location : 63.005.408 - 63.052.920
Synonym name
  • G alpha-13
  • G-protein subunit alpha-13
  • Synonym symbol(s) G13, GB13, MGC46138
    DNA
    TYPE functioning gene
    STRUCTURE 47.51 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 6311 44 377 - -
    - - 5300 - - Jurkat and HPB-ALL leukemic T cell lines -
    minor
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    cell lineage
    cell lines HPB-ALL leukemic T cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans F18G5.3
    Homologene
    FAMILY
  • G alpha family
  • G(12) subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • participating in the regulation of cell movement in response to specific ligands and in developmental angiogenesis
  • involved as modulators or transducers in various transmembrane signaling systems
  • regulating cell growth and differentiation through the monomeric Rho GTPase
  • required for the embryonic angiogenesis (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • three units : alpha, beta and gamma
  • the alpha chain contains the guanine nucleotide binding site
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARHGEF1
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • ITK interacts with GNA13 during TCR triggering, and this interaction results in tyrosine phosphorylation of GNA13
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
  • cell & other
    REGULATION
    Other regulated by myocyte-specific enhancer factor-2 (MEF2) mediating GNA13-dependent angiogenesis (Liu 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of endogenous GNA13 and MEF2 proteins in endothelial cells reduced cell proliferation and capillary tube formation (Liu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS